Group LeadersLocation and ContactMembersHistory of the GroupLines of ResearchNotable PublicationsProjectsPhD ThesesClinical TrialsNews
Dra. Victoria Álvarez

Victoria Álvarez Martínez

Elena López-Cancio Martínez

Dra. Elena López-Cancio
Group leader until april 2022

Manuel Menéndez González

  • FEA in the Neurology Department, HUCA, Cognitive Impairment Unit.

Hospital Universitario Central de Asturias (HUCA)

Avenida Hospital Universitario s/n

33011 Oviedo, Spain.

Name Organisation Activity Euraxess classification
Álvarez Carriles, Juan César SESPA Research/Clinical R2
Álvarez Escudero, María del Rocío SESPA Research/Clinical/Teaching R2
Álvarez Martínez, Victoria SESPA Research/Clinical/Teaching R4
Amorín Díaz, Manuel SESPA Research/Clinical R2
Benavente Fernández, Lorena SESPA/Universidad de Oviedo Research/Clinical/Teaching R2
Blázquez Estrada, Marta Universidad de Oviedo/SESPA Research/Clinical/Teaching R2
Calleja Puerta, Sergio SESPA Research/Clinical/Teaching R2
Castilla Silgado, Juan FINBA Research R1
Cernuda Morollón, Eva SESPA Research/Clinical R2
Coto Vilcapona, Almudena Universidad de Oviedo Research R1
Fernández Menéndez, Santiago SESPA Research/Clinical/Teaching R2
García Fernández, Ciara SESPA Research/Clinical/Teaching R2
García-Cabo Fernández, Carmen SESPA Research/Clinical R2
González Delgado, Montserrat SESPA Research/Clinical/Teaching R2
Herrero Suárez, Sara Eulogia SESPA Research/Clinical/Teaching R2
Larrosa Campo, Davinia SESPA Research/Clinical/Teaching R2
López-Cancio Martínez, Elena SESPA Research/Clinical/Teaching R3
Martínez Rodríguez, Carmen SESPA Research/Clinical/Teaching R2
Menéndez González, Manuel Universidad de Oviedo/SESPA Research/Clinical/Teaching R4
Morís De la Tassa, Germán SESPA Research/Clinical/Teaching R2
Murias Quintana, Eduardo SESPA Research/Clinical/Teaching R2
Novelli Ciotti, Antonello Universidad de Oviedo Research/Teaching R3
Oliva Nacarino, Pedro Universidad de Oviedo/SESPA Research/Clinical/Teaching R2
Oterino Durán, Agustín SESPA Research/Clinical R2
Peña Suárez, Jorge SESPA Research/Clinical/Teaching R2
Pérez Álvarez, Ángel Ignacio SESPA Research/Clinical/Teaching R2
Prendes Fernández, Patricia FINBA Research R1
Ramón Carbajo, César Universidad de Oviedo/SESPA Research/Clinical/Teaching R2
Rico Santos, María SESPA Research/Clinical/Teaching R2
Riesco Pérez, Nuria Pilar SESPA Research/Clinical/Teaching R2
Saiz Ayala, Antonio SESPA/Universidad de Oviedo Research/Clinical/Teaching R2
Sánchez Álvarez, José María SESPA Research/Clinical/Teaching R2
Santamarta Liébana, Elena SESPA Research/Clinical/Teaching R2
Santirso Rodríguez, Daniel SESPA Research/Clinical R2
Suarez San Martín, Esther SESPA Research/Clinical/Teaching R2
Vega Valdés, Pedro SESPA Research/Clinical/Teaching R2
Villafani Echazu, Javier Walter SESPA Research/Clinical/Teaching R2
Castilla Silgado, Juan FINBA Research No classification

The research group was born out of the clinical research which has been conducted in HUCA’s Neurology Department since it was established, on the basis of the extensive case history of all types of neurological diseases diagnosed in the department. This clinical research was progressively developed and systematised into specific areas of neurology, while collaborations with several basic researchers were established, of which the collaboration with the genetics division is particularly noteworthy.
The group’s work is highly translational and its lines of research are focused on gaining more in-depth knowledge of the physiopathological bases of neurological diseases. This supports the search for new diagnostic markers which can enable earlier diagnosis and improved characterisation of neurological pathologies – these generally being complex, with a significant degree of overlap between different diseases – and which can be used as prognostic factors. The group also contributes to the treatment and prevention of neurological diseases: from non-pharmacological interventions (lifestyle, risk-factor control) to new drugs (clinical trials sponsored by third parties or the group itself) and even the search for new therapeutic strategies that have not been described before (technological development projects).
Our work may currently be divided into three lines of research (Neurodegenerative Diseases, Neurological Pathology Biomarkers, and Cerebrovascular Disease). The group has obtained funding from a variety of sources, including several regional and national project grants, international consortia, R&D projects with companies and phase II to phase IV clinical trials.

Neurodegenerative Diseases

  • The genetic basis of neurodegenerative diseases (Alzheimer’s and Parkinson’s Disease)
  • Neurodegeneration biomarkers (plasma, CSF, neuroimaging)
  • Neuropsychology in neurodegenerative pathology
  • New therapies for neurodegenerative diseases

Neurological Pathology Biomarkers

  • Research on migraines and other headaches
    • Chronic migraine biomarkers
    • Response of patients with chronic migraines to treatment with botulinum toxin
    • The role of endothelial activation in the development of chronic migraines
    • Possible vascular repercussions of migraines
  • Multiple Sclerosis Biomarkers
    • Microparticles and exosomes as multiple sclerosis biomarkers
    • Monitoring therapeutic response through blood biomarkers
    • The role of circulating microvesicles in the progression of multiple sclerosis
    • The value of IgM oligoclonal bands in multiple sclerosis diagnosis
    • Development of new sensors for monitoring multiple sclerosis patients.

Cerebrovascular Disease

  • Neurovascular disease biomarkers
  • Beetz C, Koch N, Khundadze M, Zimmer G, Nietzsche S, Hertel N, Huebner AK,Mumtaz R, Schweizer M, Dirren E, Karle KN, Irintchev A, Alvarez V, Redies C,Westermann M, Kurth I, Deufel T, Kessels MM, Qualmann B, Hübner CA. A spastic paraplegia mouse model reveals REEP1-dependent ER shaping. J Clin Invest. 2014;124(6):2809.
  • Martin G, Asensi V, Montes AH, Collazos J, Alvarez V, Carton JA, Taboada F,Valle-Garay E. Role of plasma matrix-metalloproteases (MMPs) and theirpolymorphisms (SNPs) in sepsis development and outcome in ICU patients. Sci Rep. 2014 May 16;4:5002.
  • Cardo LF, Coto E, de Mena L, Ribacoba R, Mata IF, Menéndez M, Moris G, AlvarezV. lpha-synuclein transcript isoforms in three different brain regions fromParkinson’s disease and ealthy subjects in relation to the SNCA rs356165/rs11931074 polymorphisms. Neurosci Lett. 2014 562:45-9.
  • Ruiz A, Dols-Icardo O, Bullido MJ, Pastor P, Rodríguez-Rodríguez E, López deMunain A, de Pancorbo MM, Pérez-Tur J, Alvarez V, Antonell A, López-Arrieta J,Hernández I, Tárraga L, Boada M, Lleó A, Blesa R, Frank-García A, Sastre I,Razquin C, Ortega-Cubero S, Lorenzo E, Sánchez-Juan P, Combarros O, Moreno F,Gorostidi A, Elcoroaristizabal X, Baquero M, Coto E, Sánchez-Valle R, Clarimón J;dementia genetic Spanish consortium (DEGESCO). Assessing the role of the TREM2p.R47H variant as a risk factor for Alzheimer’s disease and frontotemporaldementia. Neurobiol Aging. 2014 Feb;35(2):444.
  • Cardo LF, Coto E, de Mena L, Ribacoba R, Moris G, Menéndez M, Alvarez V.Profile of microRNAs in the plasma of Parkinson’s disease patients and healthycontrols. J Neurol. 2013 May;260(5):1420-2.
  • Varga RE, Schüle R, Fadel H, Valenzuela I, Speziani F, Gonzalez M, Rudenskaia G, Nürnberg G, Thiele H, Altmüller J, Alvarez V, Gamez J, Garbern JY, Nürnberg P, Zuchner S, Beetz C.Do not trust the pedigree: reduced and sex-dependent penetrance at a novel mutation hotspot in ATL1 blurs autosomal dominant inheritance of spastic paraplegia.Hum Mutat. 2013 Jun;34(6):860-3.
  • Mata IF, Checkoway H, Hutter CM, Samii A, Roberts JW, Kim HM, Agarwal P,Alvarez V, Ribacoba R, Pastor P, Lorenzo-Betancor O, Infante J, Sierra M,Gómez-Garre P, Mir P, Ritz B, Rhodes SL, Colcher A, Van Deerlin V, Chung KA,Quinn JF, Yearout D, Martinez E, Farin FM, Wan JY, Edwards KL, Zabetian CP.Common variation in the LRRK2 gene is a risk factor for Parkinson’s disease. Mov Disord. 2012 Dec;27(14):1822-5.
  • Cernuda-Morollón E, Larrosa D, Ramón C, Vega J, Martínez-Camblor P, Pascual J. Interictal increase of CGRP levels in peripheral blood as a biomarker for chronic migraine. Neurology. 2013 Oct 1;81(14):1191-6.
  • Reglero-Real N, Alvarez-Varela A, Cernuda-Morollón E, Feito J, Marcos-Ramiro B, Fernández-Martín L, Gómez-Lechón MJ, Muntané J, Sandoval P, Majano PL, Correas I, Alonso MA, Millán J. Apicobasal polarity controls lymphocyte adhesion to hepatic epithelial cells. Cell Rep. 2014 Sep 25;8(6):1879-93.
  • Serrano-Pertierra E, Cernuda-Morollón E, Brdička T, Hoøejši V, López-Larrea C. L-plastin is involved in NKG2D recruitment into lipid rafts and NKG2D-mediated NK cell migration. J Leukoc Biol. 2014 Sep;96(3):437-45.
  • Cernuda-Morollón E, Ramón C, Martínez-Camblor P, Serrano-Pertierra E, Larrosa D, Pascual J. OnabotulinumtoxinA decreases interictal CGRP plasma levels in patients with chronic migraine. Pain. 2015 May;156(5):820-4.
  • Cernuda-Morollón E, Ramón C, Larrosa D, Alvarez R, Riesco N, Pascual J. Long-term experience with onabotulinumtoxinA in the treatment of chronic migraine: What happens after one year? Cephalalgia. 2015 Sep;35(10):864-8.
  • Cernuda-Morollón E, Martínez-Camblor P, Alvarez R, Larrosa D, Ramón C, Pascual J. Increased VIP levels in peripheral blood outside migraine attacks as a potential biomarker of cranial parasympathetic activation in chronic migraine. Cephalalgia. 2015 Apr;35(4):310-6.
  • Marcos-Ramiro B, García-Weber D, Barroso S, Feito J, Ortega MC, Cernuda-Morollón E, Reglero-Real N, Fernández-Martín L, Durán MC, Alonso MA, Correas I, Cox S, Ridley AJ, Millán J. RhoB controls endothelial barrier recovery by inhibiting Rac1 trafficking to the cell border. J Cell Biol. 2016 May 9;213(3):385-402.
  • Riesco N, Pérez-Alvarez AI, Verano L, García-Cabo C, Martínez-Ramos J, Sánchez-Lozano P, Cernuda-Morollón E, Pascual J. Prevalence of cranial autonomic parasympathetic symptoms in chronic migraine: Usefulness of a new scale. Cephalalgia. 2016 Apr;36(4):346-50.
  • Serrano-Pertierra E, Benavente L, Blanco-gelaz MA, Fernández-Martín JL, Lahoz CH, Calleja S, López- Larrea C, Cernuda-Morollón E. Lysphosphatidylcholine induces vascular somooth muscle cell membrane vesiculation: potential role in atherosclerosis through caveolin-1 regulation. Proteomics and Bioinformatics 2014; 7(10): 332-339.
  • Ramón C, Cernuda-Morollón E, Pascual J. Calcitonin gene-related peptide in peripheral blood as a biomarker for migraine. Curr Opin Neurol. 2017 Jun;30(3):281-286.
  • Tell-Marti G, Puig-Butille JA, Gimenez-Xavier P, Segu-Roig A, Potrony ,Badenas C, Alvarez V, Millán JM, Trujillo-Tiebas MJ, Ramos-Arroyo MA, Milà M,Puig S. The p. R151C Polymorphism in MC1R Gene Modifies the Age of Onset in Spanish Huntington’s Disease Patients. Mol Neurobiol. 2017 Jul;54(5):3906-3910.
  • Bustamante A, López-Cancio E,Pich S, Penalba A, Giralt D, García-Berrocoso T, Ferrer-Costa C, Gasull T, Hernández-Pérez M, Millan M, Rubiera M, Cardona P, Cano L, Quesada H, Terceño M, Silva Y, Castellanos M, Garces M, Reverté S, Ustrell X, Marés R, Baiges JJ, Serena J, Rubio F, Salas E, Dávalos A, Montaner J. Blood Biomarkers for the Early Diagnosis of Stroke: The Stroke-Chip Study. Stroke. 2017 Sep;48(9):2419-2425.
  • De Meyer SF, Andersson T, Baxter B, Bendszus M, Brouwer P, Brinjikji W, Campbell BC, Costalat V, Dávalos A, Demchuk A, Dippel D, Fiehler J, Fischer U, Gilvarry M, Gounis MJ, Gralla J, Jansen O, Jovin T, Kallmes D, Khatri P, Lees KR, López-Cancio E, Majoie C, Marquering H, Narata AP, Nogueira R, Ringleb P, Siddiqui A, Szikora I, Vale D, vonKummer R, Yoo AJ, Hacke W, Liebeskind DS; Clot Summit Group. Analyses of thrombi in acute ischemic stroke: A consensus statement on current knowledge and future directions. Int J Stroke. 2017 Aug;12(6):606-614.
  • Dávalos A, Cobo E, Molina CA, Chamorro A, de Miquel MA, Román LS, Serena J, López-Cancio E, Ribó M, Millán M, Urra X, Cardona P, Tomasello A, Castaño C, Blasco J, Aja L, Rubiera M, Gomis M, Renú A, Lara B, Martí-Fàbregas J, Jankowitz B, Cerdà N, Jovin TG; REVASCAT Trial Investigators. Safety and efficacy of thrombectomy in acute ischaemic stroke (REVASCAT): 1-year follow-up of a randomised open-label trial. Lancet Neurol. 2017 May;16(5):369-376.
  • Abilleira S, Ribera A, Cardona P, Rubiera M, López-Cancio E, Amaro S, Rodríguez-Campello A, Camps-Renom P, Cánovas D, de Miquel MA, Tomasello A, Remollo S, López-Rueda A, Vivas E, Perendreu J, Gallofré M; Catalan Stroke Code and Reperfusion Consortium. Outcomes After Direct Thrombectomy or Combined Intravenous and Endovascular Treatment Are Not Different. Stroke. 2017 Feb;48(2):375-378.
  • López-Cancio E, Ricciardi AC, Sobrino T, Cortés J, de la Ossa NP, Millán M, Hernández-Pérez M, Gomis M, Dorado L, Muñoz-Narbona L, Campos F, Arenillas JF, Dávalos A. ReportedPrestrokePhysicalActivityIsAssociatedwith Vascular EndothelialGrowth Factor Expression and Good Outcomes after Stroke. J Stroke Cerebrovasc Dis. 2017 Feb;26(2):425-430.
  • López-Cancio E, Jovin TG, Cobo E, Cerdá N, Jiménez M, Gomis M, Hernández-Pérez M, Cáceres C, Cardona P, Lara B, Renú A, Llull L, Boned S, Muchada M, Dávalos A. Endovascular treatmentimprovescognition after stroke: A secondaryanalysisof REVASCAT trial. Neurology. 2017 Jan 17;88(3):245-251.
Principal Investigator Title Reference No Duration Amount Participating Researchers
Victoria Alvarez Martinez Parkinson’s disease and cognitive impairment: identification of genetic markers through large-scale sequencing FISPI15/0078 ISCIII 2016-2018 €92,565 Germán Morís de la TassaManuel Menéndez González

Esther Suárez San Martín


Elena López-Cancio Martínez Cervical and cerebral atherosclerosis, strokes and incident cognitive impairment in the
AsIA population-based cohort
PI15/00605 ISCIII 2016-2018 €64,000
Eva Cernuda Morollón The role of activation of the trigeminovascular system and endothelial dysfunction in chronic migraines: biological, neurosonological and neuroimaging biomarkers PI14/00020I ISCIII 2015-2017 €98,615 Davinia Larrosa CamposElena Santamarta Liébana

Antonio Saiz Ayala

Elena López-Cancio Martínez The impact of physical exercise and a Mediterranean diet prior to stroke on the
prognosis in patients who undergo endovascular treatment. Multicentre
study of the Grupo Norte de Patología Cerebrovascular (Northern Cerebrovascular Pathology Group, NORDICTUS)
ICTUS Project grant – 1st edition, Cerebrovascular Diseases Group of the Sociedad Española de Neurología (Spanish Neurology Society, SEN) 2018 €9,000 Sergio Calleja PuertaLorena Benavente Fernández

Davinia Larrosa Campos

María Rico Santos

Montserrat González Delgado

María Rico Santos The implementation of ultrasonographic monitoring as an auxiliary tool for managing intraparenchymal brain haemorrhages in an acute stroke unit SONES (Spanish Neurosonology Society) grant – 3rd edition 2018 €5,000 Elena López-Cancio MartínezSergio Calleja Puerta

Lorena Benavente Fernández

Davinia Larrosa Campos

Elena López-Cancio Martínez Physical activity and a Mediterranean diet as preconditioning factors for
brain ischaemia in a stroke due to intracranial large vessel occlusion: multicentre and animal model study
PI18/01096 ISCIII 2019-2021 €93,170 Sergio Calleja PuertaDavinia Larrosa Campos

Lorena Benavente Fernández

María Rico Santos

Eduardo Murias Quintana

Pedro Vega Valdés

Manuel Menéndez González Development of an IoT platform for the selective elimination of biological
fluid molecules, tested on an Alzheimer’s disease cell model
RTC-2017-6225-1 MCIU June 2018-June 2020 €144,728
María Antonia García Prieto Validation of the 4park methodology – clinical management and care software – as a tool for communication between Parkinson’s patients and their neurologists 038_CIE_6_E Interreg POPTEC June 2018-December 2019 €22,500 Marta Blázquez Estrada


Supervisors Title PhD Student Organisation Date of Viva
Sergio Calleja Puerta Strokes and post-hospital syndrome: determinants and prognostic factors María Rico Santos Universidad de Oviedo 23/6/2017
Victoria Álvarez Martínez Parkinson’s disease: characterisation of the 3’UTR region of the SNCA and LRRK2 genes, the brain tissue and blood plasma miRNOMA Lucía Fernández Cardo Universidad de Oviedo 12/09/2014
Elena López Cancio The impact of prior physical exercise on prognosis and neurorepair for acute ischaemic strokes due to occlusion of the middle cerebral artery or the intracranial internal carotid artery: neuronal and endothelial growth factors Ana Clara Ricciardi Ciocchini Universidad Autónoma de Barcelona 23/05/2017
Eva Cernuda Morollón A study of circulating microparticles in multiple sclerosis Pedro Oliva Nacarino Universidad de Oviedo 04/12/2014
Victoria Álvarez Martínez Parkinson’s disease: the role of genetic variation in regions regulating the expression of the Parkin genes and associated
Lorena de Mena Álvarez Universidad de Oviedo 22/03/2013
Pedro Oliva Nacarino
Montserrat González Delgado
Linear measurements using magnetic resonance as brain atrophy markers in multiple sclerosis patients Ángel Pérez Álvarez Universidad de Oviedo 05/10/2018


Prospective, Non-intervention Study of Patients with Mild to Moderate Alzheimer’s Disease and their Carers in Four European Countries

  • Principal Investigator: Marta Blázquez Estrada
  • Participating Investigator: Manuel Menéndez González
  • Duration: 20/02/2017 to 20/02/2018
  • Funding Body: Merck-Sharp and Dhome Corp
  • Reference Number: MER-ALZ-2016-01

Progress Study: Post Market Clinical Follow Up Evaluating the Infinity Deep Brain Stimulation Implantable Pulse Generator System

  • Principal Investigator: Marta Blázquez Estrada
  • Participating Investigators: Esther Suárez San Martín and Ciara García Fernández
  • Duration: 06/11/2017 to 06/11/2018
  • Funding Body: SJM International INC
  • Reference Number: CRD_784/SMJ-CIP-10061

European Multicentre Retrospective Prospective Cohort Study to Observe Safinamide Safety Profile and Pattern of Use in Clinical Practice During the First Commercialization Phase

  • Principal Investigator: Marta Blázquez Estrada
  • Participating Investigators: Esther Suárez San Martín and Ciara García Fernández
  • Duration: May 2017 to December 2020
  • Funding Body: Zambon
  • Reference Number: Z7219N02

Programme for Detecting Oligoclonal Bands in CSF as a Diagnostic Support Tool for Multiple Sclerosis Patients

  • Principal Investigator: Pedro Oliva Nacarino
  • Duration: 13/05/2015 to 31/12/2015
  • Funding Body: MERCK
  • Reference Number: FUO-EM-17315

An Open-Label Study To Evaluate The Efficacy And Safety Of Ocrelizumab In Patients With Relapsing Remitting Multiple Sclerosis Who Have A Suboptimal Response To And Adequate Course Of Disease-Modifying Treatment

  • Principal Investigator: Pedro Oliva Nacarino
  • Participating Investigators: Antonio Saiz Ayala, Elena Santamarta Liébana and Jorge Peña Suárez
  • Duration: 04/05/2016 to 31/12/2018
  • Funding Body: Roche Farma
  • Reference Number: MA30005

A Prospective, Multicentre, Observational Post-authorisation Safety Study to Evaluate the Long Term Safety Profile of Lemtrada® (Alemtuzumab) Treatment in Patients with Relapsing Forms of Multiple Sclerosis

  • Principal Investigator: Pedro Oliva Nacarino
  • Duration: 2016 to 2021
  • Funding Body: Sanofi Aventis
  • Reference Number: OBS13434

Anti-Alpha-4 Integrin Antibodies in the Treatment of Multiple Sclerosis

  • Principal Investigators: Pedro Oliva Nacarino and Eva Cernuda Morollón
  • Duration: 2013 to 2015
  • Funding Body: BiogenIDEC

Laboratory Techniques to Support the Diagnosis, Classification, Prognosis and Monitoring of Therapeutic Response in Multiple Sclerosis Patients

  • Principal Investigator: Pedro Oliva Nacarino
  • Participating Investigator: Eva Cernuda Morollón
  • Duration: 2014 to 2015
  • Funding Body: Sanofi Aventis

A Phase 2, Double-Blind, Randomised, Placebo-Controlled Study to Evaluate the Safety, Tolerability, and Efficacy of ANAVEX2-73 for Cognitive Impairment in Patients with Parkinson’s Disease with Dementia

  • Principal Investigator: Marta Blázquez Estrada
  • Participating Investigator: Manuel Menéndez González
  • Duration: 2018
  • Reference Number: ANAVEX-2-73-001