Ana Suárez Díaz obtained her Bachelor’s degree in Biology from the Universidad de Oviedo. She specialised in Clinical Immunology after her period of training as a Resident Intern Biologist in the Immunology Department of the Hospital Universitario Central de Asturias (HUCA), where she combined clinical practice with basic and clinical research, as well as completing her PhD thesis.
She subsequently took up a position as an Immunology lecturer in the Department of Functional Biology at the Universidad de Oviedo, where she created a research group on Cellular and Molecular Immunology, working in close collaboration with specialist health professionals from several HUCA departments. Since then she has obtained national and regional competitive funding for several research projects, most of which have been genetic and functional studies of autoimmune pathologies, cytokines and minority subpopulations of cells associated with immunity disorders. More recently, the group’s research has focused on endothelial damage and cardiovascular risk in several inflammatory pathologies.
Over the last five years, she has been principal investigator on two health research projects funded by the Instituto de Salud Carlos III, whose results have been published in over 50 scientific articles in mid- and high-impact, peer-reviewed journals.
Departamento de Biología Funcional – Facultad de Medicina
Julián Clavería s/n
33006 Oviedo, Spain.
Telephone: +34 985102789
E-mail: anasua@uniovi.es
| Name | Organisation | Activity | Euraxess classification |
|---|---|---|---|
| Abal Ferrer, Francisco | SESPA | Research/Clinical | R2 |
| Alperi López, Mercedes | SESPA | Research/Clinical | R2 |
| Ballina García, Francisco Javier | SESPA/Universidad de Oviedo | Research/Clinical/Teaching | R2 |
| Caminal Montero, Luis | SESPA | Research/Clinical | R2 |
| López Suárez, Patricia | Universidad de Oviedo | Research/Teaching | R3 |
| Martínez Zapico, Aleida | SESPA | Research/Clinical | R2 |
| Mozo Avellaneda, Lourdes | SESPA | Research/Clinical | R2 |
| Rodríguez Carrio, Javier | Universidad de Oviedo | Research/Teaching | R2 |
| Suárez Díaz, Ana | Universidad de Oviedo | Research/Teaching | R4 |
This multidisciplinary research group is coordinated by the Department of Functional Biology’s Immunology section at the Universidad de Oviedo. The group is made up of basic and clinical researchers, working on projects in the field of inflammatory diseases.
Initially, the group’s research focused on patients with autoimmune diseases, analysing various factors at the genetic, molecular and cellular levels. Its work later expanded to include research on a range of chronic inflammatory diseases. Our newest line of research analyses cardiovascular disease in inflammatory and autoimmune pathologies, given its prevalence in patients with these conditions. The research aims to identify new biomarkers for vascular dysfunction, to enable early detection and appropriate risk stratification and learn about the mechanisms which cause the increase in damage and the deterioration of endothelial repair that lie behind vascular disease in these pathologies. To meet this objective, we perform in vitro and ex vivo phenotypic and functional analyses of various cell subpopulations, quantify circulating molecules, analyse gene and protein expression and identify genetic polymorphism, all of which is analysed in relation to the clinical data. This type of study can potentially be extended to other physiological or pathological contexts in which the evaluation of inflammatory and immunopathological markers is relevant.
- Inflammatory and autoimmune diseases
- Endothelial dysfunction and cardiovascular risk
- Inflammatory and immunopathological markers
- AUTHORS: Lopez P, Scheel-Toellner D, Rodriguez-Carrio J, Caminal-Montero L, Gordon C, Suárez A.
TITLE: Interferon-alpha-induced B-lymphocyte stimulator expression and mobilization in healthy and systemic lupus erthymatosus monocytes.
Rheumatology (Oxford). 2014 Jun 18. 53(12):2249-58. RHEUMATOLOGY. IF: 4.818 (4/30). Q1. - AUTHORS: Rodríguez-Carrio J, Alperi-López M, López P, Alonso-Castro S, Carro-Esteban SR, Ballina-García FJ, Suárez A.
TITLE: Altered profile of circulating microparticles in Rheumatoid Arthritis patients.
Clin Sci (Lond). 2015 Apr; 128(7):437-48. MEDICINE, RESEARCH & EXPERIMENTAL. IF: 4.936 (14/128). Q1. - AUTHORS: Rodríguez-Carrio J, Alperi-López M, López P, Alonso-Castro S, Ballina-García FJ and Suárez A.
TITLE: Angiogenic T cells are decreased in Rheumatoid Arthritis patients.
Ann Rheum Dis. 2015 May; 74(5):921-7. RHEUMATOLOGY. IF: 12.811 (1/30). D1. - AUTHORS: Rodríguez-Carrio J, Alperi-López M, López P, Ballina-García FJ, Suárez A.
TITLE: Good response to tumour necrosis factor alpha blockade results in an angiogenic T cell recovery in rheumatoid arthritis patients.
Rheumatology (Oxford). 2015 Jun; 54(6):1129-31. RHEUMATOLOGY. IF: 4.818 (4/30). Q1. - AUTHORS: Rodríguez-Carrio J, Alperi-López M, López P, Alonso-Castro S, Ballina-García FJ and Suárez A.
TITLE: Red Cell Distribution Width is associated with cardiovascular risk and disease parameters in Rheumatoid Arthritis.
Rheumatology 2015 Apr; 54(4):641-6. RHEUMATOLOGY. IF: 4.818 (4/30). Q1. - AUTHORS: Rodríguez-Carrio J, Alperi-López M, López P, Alonso-Castro S, Rubén Carro-Esteban SR, Ballina-García FJ, Suárez
TITLE: A Red Cell Distribution Width is associated with Endothelial Progenitor Cell depletion and vascular-related mediators in Rheumatoid Arthritis.
Atherosclerosis. 2015 Mar 10; 240(1):131-136. PERIPHERAL VASCULAR DISEASE. IF: 4.239 (10/63). Q1. - AUTHORS: Rodríguez-Carrio J, Alperi-López M, López P, Alonso-Castro S, Ballina-García FJ, Suárez A.
TITLE: TNFα polymorphism as marker of immunosenescence for rheumatoid arthritis patients.
Exp Gerontol. 2015 Jan; 61:123-9. GERIATRICS & GERONTOLOGY. IF: 3.340 (12/49). Q1. - AUTHORS: Rodríguez-Carrio J, López P and Suárez A.
TITLE: Type I IFNs as biomarkers in rheumatoid arthritis: towards disease profiling and personalized medicine.
Clinical Science (2015) 128(8): 449–464. MEDICINE, RESEARCH & EXPERIMENTAL. IF: 4.936 (14/128). Q1. - AUTHORS: Rodríguez-Carrio J, Alperi-López M, López P, Ballina-García FJ, Abal F, Suárez A.
TITLE: Antibodies to high-density lipoproteins are associated with inflammation and cardiovascular disease in rheumatoid arthritis patients.
Transl Res. 2015 Dec; 166(6):529-39. MEDICINE, RESEARCH & EXPERIMENTAL. IF: 4.652 (19/128). Q1. - AUTHORS: Lopez P; Rodríguez-Carrio J; Caminal-Montero L; Mozo L; Suárez A.
TITLE: A pathogenic IFNα, BLyS and IL-17 axis in SLE patients.
Sci Rep. 2016; 6:20651. MULTIDISCIPLINARY SCIENCES. IF: 4.259 (10/64). Q1. - AUTHORS: Rodríguez-Carrio J, López-Mejías R, Alperi-López M, López P, Ballina-García FJ, González-Gay MA, Suárez A.
TITLE: PON 1 activity is modulated by rs662 polymorphism and IgG anti-HDL antibodies in Rheumatoid Arthritis patients: potential implications for CV disease.
Arthritis Rheumatol. 2016 Jun; 68(6): 1367-76. RHEUMATOLOGY. IF: 6.918 (3/30). D1. - AUTHORS: López P, de Paz B, Rodríguez-Carrio J, Hevia A, Sánchez B, Margolles A and Suárez A.
TITLE: Th17 responses and natural IgM antibodies are related to gut microbiota composition in systemic lupus erythematosus patients.
Sci Rep. 2016 Apr 5; 6:24072. MULTIDISCIPLINARY SCIENCES. IF: 4.259 (10/64). Q1. - AUTHORS: López P, Sánchez B, Margolles A, Suárez A.
TITLE: Intestinal dysbiosis in SLE: cause or consequence?. Current Opinion in Rheumatology.
2016 Sep; 28(5):515-22. RHEUMATOLOGY. IF: 4.475 (7/30). Q1. - AUTHORS: Rodríguez-Carrio J, Alperi-López, M López-Mejías R, López P, Ballina-García FJ, Abal F, González-Gay MA, Suárez A.
TITLE: Antibodies to paraoxonase 1 are associated with oxidant status and endothelial activation in rheumatoid Arthritis.
Clin Sci (Lond). 2016 Nov 1; 130(21):1889-99. MEDICINE, RESEARCH & EXPERIMENTAL. IF: 4.936 (14/128). Q1. - AUTHORS: Rodríguez-Carrio J, López P, Sánchez B, González S, Gueimonde M, Margolles A, de los Reyes-Gavilán CG, Suárez A.
TITLE: Intestinal dysbiosis is associated with altered SCFA and free fatty acids in systemic lupus erythematosus.
Frontiers Immunology 2017. Jan 23; 8:23. IMMUNOLOGY. IF: 6.429 (21/150). Q1. - AUTHORS: López P, Rodríguez-Carrio J, Martínez-Zapico A, Caminal-Montero L and Suárez A.
TITLE: Circulating microparticle subpopulations in Systemic Lupus Erythematosus are affected by disease activity.
Int J Cardiology 2017; 236: 138-144. CARDIAC & CARDIOVASCULAR SYSTEMS. IF: 6.189 (16/126). Q1. - AUTHORS: Rodríguez-Carrio J, Alperi-López M, López P, López-Mejías R, Alonso-Castro S, Abal F, Ballina-García FJ, González-Gay MA, Suárez A.
TITLE: High triglycerides and low HDL-c lipid profile in rheumatoid arthritis: a potential link among inflammation, oxidative status and dysfunctional HDL.
Journal of Clinical Lipidology 2017; 11(4): 1043-1054.e2. PHARMACOLOGY & PHARMACY. IF: 5.812 (17/216). D1. - AUTHORS: López P, Rodríguez-Carrio J, Martínez-Zapico A, Pérez-Álvarez AI, López-Mejías R, Benavente L, Mozo L, Caminal-Montero L, González-Gay MA, Suárez A.
TITLE: Serum levels of anti-PON1 and anti-HDL antibodies as potential biomarkers of premature atherosclerosis in Systemic Lupus Erythematosus.
Thombosis and Haemostasis 2017. Oct 10; 117(11). PERIPHERAL VASCULAR DISEASE. IF: 5.627 (6/63). D1. - AUTHORS: Rodríguez-Carrio J, Salazar N, Margolles A, González S, Gueimonde M, de los Reyes-Gavilán CG, Suárez A.
TITLE: Free Fatty Acids Profiles Are Related to Gut Microbiota Signatures and Short-Chain Fatty Acids.
Frontiers Immunology. 2017. Jul 24; 8:823. Front Immunol. 2018 Jan 16;8:2007. IMMUNOLOGY. IF: 6.429 (21/151). Q1. - AUTHORS: Rodríguez-Carrio J, Alperi-López M, López P, Ballina-García FJ, Suárez A.
TITLE: Heterogeneity of the type I interferon signature in rheumatoid arthritis: a potential limitation for its use as a clinical biomarker.
Frontiers Immunology. 2018. Jan 16; 8:2007. IMMUNOLOGY. IF: 6.429 (21/151). Q1.
| Principal Investigator | Title | Funding Body | Reference No | Participating Institutions | Duration | Funding |
|---|---|---|---|---|---|---|
| Ana Suárez Díaz | Identification of early biomarkers for endothelial damage and cardiovascular risk in autoimmunity. | Instituto de Salud Carlos III, Health Research Fund (FIS). | FIS PI16/00113 | Universidad de Oviedo and Hospital Universitario Central de Asturias | January 2017 – December 2019 | €92,565 |
| Javier Rodríguez Carrio | Cardiovascular disease and rheumatoid arthritis: the importance of the preclinical scenario. | Fundación Española de Reumatología (Spanish Rheumatology Foundation) | FER043/2016 | Universidad de Oviedo and Hospital Universitario Central de Asturias | September 2016 – September 2018 | €20,000 |
| Íñigo Lozano Martínez-Luengas | The relationship between restenosis in coronary stents and excessive cutaneous scarring: identification of systemic biomarkers associated with a worsened restenosis rate. | MEDTRONIC | FINBA, SESPA and the Universidad de Oviedo | May 2017 – April 2019 | €43,000 | |
| Clara González de los Reyes-Gavilán | Human Microbiota, Food and Health . | Regional Research Plan of the Principado de Asturias (FICYT) | GRUPIN14-043 | Instituto de Productos Lácteos de Asturias (IPLA–CSIC), SESPA and the Universidad de Oviedo | December 2014 – December 2017 | €206,400 |
| Ana Suárez Díaz | Identification of early biomarkers for endothelial damage and cardiovascular risk in autoimmunity. | Instituto de Salud Carlos III, Health Research Fund. | FIS PI16/00113 | Universidad de Oviedo and Hospital Universitario Central de Asturias | January 2017 – December 2019 | €92,565 |
| Ana Suárez Díaz | Identification of biomarkers for endothelial damage in autoimmunity by studying circulating endothelial progenitor cells and their relationship to subpopulations of t-lymphocytes and cytokines. | Instituto de Salud Carlos III, Health Research Fund. | FIS PI12/00523 | Universidad de Oviedo and Hospital Universitario Central de Asturias | January 2013 – December 2015 | €74,410 |
| Ana Suárez Díaz | Systemic lupus erythematosus research. | GlaxoSmithkline. Fundación Universidad de Oviedo | FUO-EM-267-12 | Universidad de Oviedo and Hospital Universitario Central de Asturias | October 2013 – December 2015 | €12,710 |
| Ana Suárez Díaz | Identification of biomarkers for endothelial damage in autoimmunity by studying circulating endothelial progenitor cells and their relationship to subpopulations of t-lymphocytes and cytokines | Regional Research Plan of the Principado de Asturias (FICYT) | COF13-0122 | Universidad de Oviedo | January 2014 – December 2014 | €24,000 |
| Title | PhD Student | University | Department | Date of Viva | Classification |
|---|---|---|---|---|---|
| Biomarkers for endothelial damage and cardiovascular risk in rheumatoid arthritis patients. | Javier Rodríguez Carrio | Oviedo | Functional Biology | July 2015 | Summa Cum Laude. INTERNATIONAL HONOURS. OUTSTANDING PHD AWARD |
| Genetic polymorphism and response to corticosteroids in rheumatoid arthritis patients: the effect on regulatory T cells and cytokines . | Banesa de Paz Cazón | Oviedo | Functional Biology | February 2016 | Summa Cum Laude |
| Cardiovascular disease in systemic lupus erythematosus patients: prevalence and biomarkers for endothelial damage. | Aleida Martínez Zapico | Oviedo | Functional Biology | 27-07-2018 | Summa Cum Laude |
| Inventors | Title | Owner | Date Issued | Patent No | International Publication Date | International Publication No |
|---|---|---|---|---|---|---|
| Javier Rodríguez Carrio Patricia López Suárez Ana Suárez Díaz |
Method for assessing non-traditional cardiovascular risk by detecting anti-high-density lipoprotein antibodies, an immunosensor and a kit for using it. | Universidad de Oviedo | 27-04-2016 | ES2547582_B2 | 03-11-2016 | WO 2016/174282 A1 |
- Summary of the Patricia López Suárez Seminar (30/1/2019)
