Heart Disease

César Morís de la Tassa

• Tenured Lecturer in the Medicine Department, Universidad de Oviedo, Cardiology specialist.
• Coordinator of the Heart Clinical Management Division of the Hospital Universitario Central de Asturias (HUCA). Position: Department Head.

Name	Organisation	Activity	Euraxess classification
Almendárez Lacayo, Marcel Gabriel	SESPA	Research/Clinical	R1
Alonso Arias, Rebeca	SESPA	Research/Clinical/Teaching	R3
Alonso Pérez, Manuel	SESPA	Research/Clinical	R2
Alperi García, Alberto	FINBA	Research/Clinical	R2
Álvarez Marcos, Francisco	SESPA	Research	R2
Álvarez Velasco, Rut	SESPA	Research/Clinical	R2
Antuña Álvarez, Paula	SESPA	Research/Clinical	R2
Avanzas Fernández, Pablo	SESPA	Research/Clinical/Teaching	R3
Ayesta López, Ana	SESPA	Research	R2
Bueno García, Eva	FINBA	Research	R1
Calvo Cuervo, David	SESPA	Research/Clinical/Teaching	R3
Colunga Blanco, Santiago	SESPA	Research/Clinical/Teaching	R2
del Río García, Álvaro	FINBA	Research	R1
Díaz Méndez, Rocío	SESPA	Research/Clinical/Teaching	R2
Díaz Molina, Beatriz	SESPA	Research/Clinical/Teaching	R3
García Iglesias, Daniel	SESPA	Research/Clinical/Teaching	R2
García Ruiz, José Manuel	SESPA	Research/Clinical/Teaching	R2
García Torre, Alejandra	FINBA	Research	R1
González Vasserot, Mar	SESPA	Research/Clinical/Teaching	R2
Hernández-Vaquero Panizo, Daniel	SESPA	Research/Clinical/Teaching	R3
Lambert Rodríguez, José Luis	SESPA	Research/Clinical/Teaching	R3
Lorca Gutiérrez, Rebeca	SESPA	Research/Clinical	R2
Lozano Martínez-Luengas, Íñigo Manuel	SESPA	Research/Clinical/Teaching	R3
Martín Fernández, María	SESPA	Research/Clinical/Teaching	R2
Mohamedi Munarriz, Yamina	FINBA	Research	R2
Morís de la Tassa, César	SESPA/Universidad de Oviedo	Research/Clinical/Teaching	R4
Pascual Calleja, Isaac	SESPA	Research/Clinical/Teaching	R2
Pérez Díez, Diego	SESPA	Research/Clinical/Teaching	R2
Rodríguez García, María Isabel	FINBA	Research	R3
Rondán Murillo, Juan	SESPA	Research/Clinical/Teaching	R2
Rozado Castaño, José	SESPA	Research/Clinical/Teaching	R2
Rubín López, José Manuel	SESPA	Research/Clinical/Teaching	R2
Samaniego Lampón, Beatriz	SESPA	Research/Clinical/Teaching	R2
Testa Alonso, David	SESPA	Research	CLASSIFICATION NOT AVAILABLE
Valverde André, Irene	SESPA	Research/Clinical/Teaching	R2
Vegas Valle, José Miguel	SESPA	Research/Clinical/Teaching	R2
Moro García, Marco Antonio	SESPA	Research	No classification

Arrhythmias and arrhythmogenic mechanisms

1. Characterisation of the mechanisms for the maintenance of persistent human atrial fibrillation and their response to therapeutic intervention through radiofrequency ablation
2. Determinism in human ventricular fibrillation. Periodic high-frequency centrifugal activity connected to the areas of greatest electrophysiological heterogeneity in the ventricular myocardium.
3. Electrocardiographic quantification using non-linear signal analysis methods: diagnostic and predictive value for Brugada Syndrome.
4. Treatment of the bipolar endocardial signal during atrial fibrillation and analysis of how its behaviour changes over time with each progressive stage of the disease in humans.
5. Correction of the QT interval when severe ventricular depolarisation disorders are present.
6. Mechanisms and psychometric characterisation of patients with supraventricular tachycardia.

Valvular pathology

1. Valvular prosthesis - patient mismatch.
2. Percutaneous treatment of aortic valve disease.
3. Markers of predisposition to aortic pathology.

Myocardial lesions

1. Treatment and progress after heart transplant.
2. The impact of resynchronisation on cost and the quality of life of heart failure patients.

Immunology of cardiovascular diseases

1. Alterations in t-lymphocytes in cardiovascular pathology.
2. The impact of CMV infection on cardiovascular pathology.

 

• Calvo D, Rubín J, Pérez D, Jalife J. Spectral analysis of electrograms in a substrate modified by radiofrequency ablation reveals similarities between organized and disorganized atrial rhythms. Heart Rhythm. 2014;11:2306–2309.
• Calvo D, Atienza F, Saiz J, Martínez L, Ávila P, Rubín J, Herreros B, Arenal Á, García-Fernández J, Ferrer A, Sebastián R, Martínez-Camblor P, Jalife J, Berenfeld O. Ventricular Tachycardia and Early Fibrillation in Patients With Brugada Syndrome and Ischemic Cardiomyopathy Show Predictable Frequency-Phase Properties on the Precordial ECG Consistent With the Respective Arrhythmogenic Substrate. Circ Arrhythm Electrophysiol. 2015;8:1133-1143.
• Calvo D, Rubín JM, Pérez D, Gómez J, Flórez JP, Avanzas P, García-Ruíz JM, de la Hera JM, Reguero J, Coto E, Morís C. Time-dependent responses to provocative testing with flecainide in the diagnosis of Brugada syndrome. Heart Rhythm. 2015;12:350-357.
• Calvo D, Ávila P, García-Fernández FJ, Pachón M, Bravo L, Eidelman G, Hernández J, Miracle ÁL, Rubín J, Pérez D, Arenal Á, Atienza F, Jimenez-Candil J, Arias MÁ, Datino T, Martínez-Camblor P, Gonzalez-Torrecilla E, Almendral J. Differential Responses of the Septal Ventricle and the Atrial Signals During Ongoing Entrainment: A Method to Differentiate Orthodromic Reciprocating Tachycardia Using Septal Accessory Pathways From Atypical Atrioventricular Nodal Reentry. Circ Arrhythm Electrophysiol. 2015;8:1201-1209.
• David Calvo, José Jalife. Mechanoelectric Feedback in the Ischemic Myocardium: An Interplay That Modulates Susceptibility to Fibrillation. Revista Española de cardiología. 2013. Mar;66(3):168-170.
• David Calvo, Flórez JP, Valverde I, Rubín J, Pérez D, Vasserot MG, Rodríguez-Reguero J, Avanzas P, de la Hera JM, Gómez J, Coto E, Martínez-Camblor P, Morís C. Surveillance after Cardiac Arrest in patients with Brugada Syndrome without an implantable defibrillator: An alarm effect of the previous Syncope. Int J Cardiol. 2016 May 13;218:69-74.
• Riobello C, Gómez J, Gil-Peña H, Tranche S, Reguero JR, de la Hera JM, Delgado E, Calvo D, Morís C, Santos F, Coto-Segura P, Iglesias S, Alonso B, Alvarez V, Coto E. KCNQ1 gene variants in the risk for type 2 diabetes and impaired renal function in the Spanish Renastur cohort. Mol Cell Endocrinol. 2016 May 15;427:86-91.
• Salgado R, Martín J, Martínez J, Alzueta J, Viñolas X, Fernández J, Molina M, Pérez L, Calvo D, García J. Small-Caliber Lead Failure After Generator Exchange. J Cardiovasc Electrophysiol. 2016;27(7):846-50.
• Rodrigo M, Climent AM, Liberos A, Calvo D, Fernández-Avilés F, Berenfeld O, Atienza F, Guillem MS. Identification of Dominant Excitation Patterns and Sources of Atrial Fibrillation by Causality Analysis. Ann Biomed Eng. 2016;44(8):2364-76.
• Loughlin G, Romaniega TD, Garcia-Fernandez J, Calvo D, Salgado R, Alonso A, Li X, Arenal A, González-Torrecilla E, Atienza F, Fernández-Avilés F. Immediate post-procedure bridging with unfractioned heparin versus low molecular weight heparin in patients undergoing radiofrequency ablation for atrial fibrillation with an interrupted oral anticoagulation strategy. J Interv Card Electrophysiol. 2016;45(2):149-58.
• Ruiz-Salas A, Datino T, Peña-Hernández J, Calvo D, Alzueta J. Inappropriate shock due to late dislocation of electrode. Int J Cardiol. 2015 Nov 15;199:229-31.
• Hernandez-Vaquero D, Garcia JM, Diaz R, Calvo D, Khalpey Z, Hernández E, Rodriguez V, Morís C, Llosa JC. Moderate patient-prosthesis mismatch predicts cardiac events and advanced functional class in young and middle-aged patients undergoing surgery due to severe aortic stenosis. J Card Surg. 2014;29:127-33.
• Pascual I, Moris C, Avanzas P. Beta-Blockers and Calcium Channel Blockers: First Line Agents. Cardiovasc Drugs Ther. 2016;30:357-65.
• Pascual I, Muñoz-García AJ, López-Otero D, Avanzas P, Jimenez-Navarro MF, Cid-Alvarez B, Del Valle R, Alonso-Briales JH, Ocaranza-Sanchez R, Hernández JM,Trillo-Nouche R, Morís C. Transcatheter aortic valve implantation in very elderly patients: immediate results and medium term follow-up. J Geriatr Cardiol. 2015;12:340-5.
• García-Álvarez A, Pereda D, García-Lunar I, Sanz-Rosa D, Fernández-Jiménez R, García-Prieto J, Nuño-Ayala M, Sierra F, Santiago E, Sandoval E, Campelos P, Agüero J, Pizarro G, Peinado VI, Fernández-Friera L, García-Ruiz JM, Barberá JA, Castellá M, Sabaté M, Fuster V, Ibañez B. Beta-3 adrenergic agonists reduce pulmonary vascular resistance and improve right ventricular performance in a porcine model of chronic pulmonary hypertension. Basic Res Cardiol. 2016 Jul;111(4):49.
• López-Melgar B, Fernández-Friera L, Sánchez-González J, Vilchez JP, Cecconi A, Mateo J, Peñalvo JL, Oliva B, García-Ruiz JM, Kauffman S, Jiménez-Borreguero LJ, Ruiz-Cabello J, Fernández-Ortiz A, Ibáñez B, Fuster V. Accurate quantification of atherosclerotic plaque volume by 3D vascular ultrasound using the volumetric linear array method. Atherosclerosis. 2016 May;248:230-7
• García-Ruiz JM, Fernández-Jiménez R, García-Alvarez A, Pizarro G, Galán-Arriola C, Fernández-Friera L, Mateos A, Nuno-Ayala M, Aguero J, Sánchez-González J, García-Prieto J, López-Melgar B, Martínez-Tenorio P, López-Martín GJ, Macías A, Pérez-Asenjo B, Cabrera JA, Fernández-Ortiz A, Fuster V, Ibáñez B. Impact of the timing of metoprolol administration during ongoing STEMI on infarct size and ventricular function: a METOCARD-CNIC trial substudy with an experimental validation. J Am Coll Cardiol. 2016 May 10;67(18):2093-104.
• Hausenloy DJ, Kharbanda R, Rahbek Schmidt M, Møller UK, Ravkilde J, Okkels Jensen L, Engstrøm T, Garcia Ruiz JM, Radovanovic N, Christensen EF, Sørensen HT, Ramlall M, Bulluck H, Evans R, Nicholas J, Knight R, Clayton T, Yellon DM, Bøtker HE. Effect of remote ischaemic conditioning on clinical outcomes in patients presenting with an ST-segment elevation myocardial infarction undergoing primary percutaneous coronary intervention. Eur Heart J. 2015;36(29):1846-8.
• Díaz-Molina B, Lambert JL, Víchez FG, Cadenas F, Bernardo MJ, Velasco E, Martín M, Morís C. Quality of life according to urgency status in de novo heart transplant recipients. Transplantation Proceedings 2016; 48: 3024-6.
• Fernandez Alvarez R, Rubinos Cuadrado G, Alonso Arias R, Cascon Hernandez JA, Palomo Antequera B, Iscar Urrutia M, Casan Clara P. Snoring as a Determinant Factor of Oxidative Stress in the Airway of Patients with Obstructive Sleep Apnea. Lung. 2016; 194 (3): 469-73.
• Moro-García MA, López Iglesias F, Avanzas P, Echeverría A, López-Larrea C, Morís de la Tassa C, Alonso-Arias R. Disease complexity in acute coronary syndrome is related to the patient's immunological status. Int J Cardiol. 2015; 189: 115-23.
• Pascual I, Carro A, Avanzas P, Hernández-Vaquero D, Díaz R, Rozado J, Lorca R, Martín M, Silva J, Morís C. Vascular approaches for transcatheter aortic valve implantation. J Thorac Dis. 2017 May;9(Suppl 6):S478-S487.
• Hernandez-Vaquero D, Diaz R, Pascual I, Rozado J, De la Hera JM, Leon V, Avanzas P, Martín M, García-Iglesias D, Calvo D, Silva J, Moris C. The Prevalence of Patient-Prosthesis Mismatch Can Be Reduced Using the Trifecta Aortic Prosthesis. Ann Thorac Surg. 2018 Jan;105(1):144-151.
• Díaz R, Hernández-Vaquero D, Silva J, Pascual I, de la Hera JM, León V, Martín M, Barriales V, Colunga S, Del Valle R, Morís C. Real Structural Valve Deterioration of the Mitroflow Aortic Prosthesis: Competing Risk Analysis. Rev Esp Cardiol (Engl Ed). 2017 Dec;70(12):1074-1081.
• García-Prieto J, Villena-Gutiérrez R, Gómez M, Bernardo E, Pun-García A, García-Lunar I, Crainiciuc G, Fernández-Jiménez R, Sreeramkumar V, Bourio-Martínez R, García-Ruiz JM, Del Valle AS, Sanz-Rosa D, Pizarro G, Fernández-Ortiz A, Hidalgo A, Fuster V, Ibanez B. Neutrophil stunning by metoprolol reduces infarct size. Nat Commun. 2017 Apr 18;8:14780.

Principal Investigator	Title	Funding Body	Reference No	Duration	Amount
Daniel Hernández-Vaquero	Medium-term degeneration of a bovine pericardial aortic prosthesis	Instituto de Salud Carlos III	PI15/00258	2016-2018	€22,385
Rebeca Alonso Arias	Characterisation of the antigen specificity and functional activity of CD4+CD28null t-lymphocytes in patients with chronic heart failure: possible pathogenic implications	Instituto de Salud Carlos III	PI14/01566	2015-2017	€94,985
Rebeca Alonso Arias	Quantitative and functional alterations in naïve t-lymphocytes in patients with secondary systemic inflammation resulting from chronic heart failure	Instituto de Salud Carlos III	PI17/00714	2018-2020	€188,457.50

Supervisors	Title	PhD Student	Organisation	Date of Viva
Julio Ángel Mayol MartínezJacobo Silva Guisasola Luis Barneo Sierra	External validation of the EuroSCORE II in octogenarian patients who have undergone aortic valve replacement surgery	Rocío Díaz	Universidad Complutense	18-9-2017

SURTAVI - Clinical Trial Comparing Surgical Replacement and Transcatheter Aortic Valve Implantation.

• Sponsor: MEDTRONIC
• https://clinicaltrials.gov/ct2/show/NCT0158691
• Started in 2017

CoreValve™ Evolut R™ FORWARD Study (FORWARD)

• Sponsor: MEDTRONIC
• https://clinicaltrials.gov/ct2/show/NCT02592369
• Started in 2017

Effect of Remote Ischaemic Conditioning on Clinical Outcomes in ST-elevation Myocardial Infarction Patients Undergoing Primary Percutaneous Coronary Intervention: A Multicentre Randomised Controlled Clinical Study. CONDI 2

• Sponsor: Danish Strategic Research Council.
• Completed in: 2014 – 2017

ATPCI Study -The Efficacy and Safety of Trimetazidine in Patients with Angina Pectoris having been Treated by Percutaneous Coronary Intervention.

• Sponsor: SERVIER.
• Completed in: 2014

GALILEO- Multicentre Study Comparing a Rivaroxaban-based Antithrombotic Strategy to an Antiplatelet-based Strategy after Transcatheter Aortic Valve Replacement (TAVR).

• Bayer HealthCare.
• Completed in: 2015

COMPLETE- Comparison of Complete vs Single Vessel Revascularisation after a Primary Angioplasty in Patients with Acute Coronary Syndrome

• Sponsor: Population Health Research Institute (PHRI).
• Completed in: 2015

Angiography Study of BioNIR Drug Eluting Stent System (NIREUS)

• Sponsor: Medinol
• https://clinicaltrials.gov/ct2/show/NCT01995500

ODYSSEY Outcomes: Evaluation of Cardiovascular Outcomes After an Acute Coronary Syndrome During Treatment With Alirocumab

• Sponsor: Sanofi
• Code: https://clinicaltrials.gov/ct2/show/NCT01663402

Oxygen carrying blood substitutes and their use as delivery vehicles

• Inventors: Borja Ibáñez Cabeza, José Manuel García-Ruiz, Jauma Agüero Ramon-Llin, Rodrigo Fernández-Jiménez, Valentín Fuster Carulla, Enrique Lara-Pezzi, Juan Antonio Bernal Rodríguez, Carlos Galán-Arriola, Andrés Pun García, Enda Joseph Clinton
• Ref No: EP17 382 040.8.
• First application: 28 January 2017