Paediatrics

Fernando Santos Rodríguez

• Clinical Professor of Paediatrics, Universidad de Oviedo
• Head of the Paediatric Department, Director of the Paediatric Clinical Management Division of HUCA

Name	Organisation	Activity	Euraxess classification
Bousoño García, Carlos	Universidad de Oviedo/SESPA	Research/Clinical/Teaching	R3
Alonso Álvarez, María Agustina	SESPA	Research/Clinical	R2
Blanco Lago, Raquel	SESPA	Research/Clinical/Teaching	R2
Calle Miguel, Laura	SESPA	Research/Clinical	R2
Concha Torre, Andrés	SESPA	Research/Clinical	R2
Díaz Martín, Juan José	SESPA	Research/Clinical	R3
Fernández Colomer, Belén	SESPA	Research/Clinical	R3
Fernández Sánchez, María Luisa	Universidad de Oviedo	Research/Teaching	R3
Fuente Pérez, Rocío	FINBA	Research	R2
García López, Enrique	SESPA	Research/Clinical	R2
Gil Peña, Helena	SESPA	Research/Clinical	R4
González Jiménez, David	SESPA	Research/Clinical	R2
Hedrera Fernández, Antonio	SESPA	Research/Clinical	R2
Lareu Vidal, Sonia	SESPA	Research/Clinical	R2
López García, Jose Manuel	SESPA	Research/Teaching	R3
Málaga Diéguez, Ignacio	SESPA	Research/Clinical	R2
Mayordomo Colunga, Juan	SESPA	Research/Clinical	R2
Medina Villanueva, Alberto	SESPA	Research/Clinical	R2
Mantecón Fernández, Laura	SESPA	Research/Clinical	R2
Ordóñez Álvarez, Flor Ángel	SESPA	Research/Clinical	R2
Rey Galán, Corsino	SESPA/Universidad de Oviedo	Research/Clinical/Teaching	R4
Rodríguez Rubio, Enrique	FINBA	Research	R2
Rodríguez Suárez, Julián	SESPA	Research/Clinical/Teaching	R2
Solís Sánchez, Gonzalo	SESPA	Research/Clinical/Teaching	R3
Suárez Rodríguez, Marta	SESPA	Research/Clinical	R2
Vivanco Allende, Ana	SESPA	Research/Clinical	R2
Alonso Durán, Laura	FINBA	Research	No classification
Suárez González, Marta	SESPA	Research	No classification

Primary tubulopathies

Nutrition and growth

• Growth, nutrition and mineral metabolism in chronic kidney disease
• Neonatal nutrition
• Nutrition and cardiovascular health

Critically-ill paediatric patients

• Biomarkers and prognostic scales
• Optimisation of mechanical ventilation

• Claramunt D, Gil-Peña H, Fuente R, García-López E, Hernández Frías O, Ordoñez FA,Rodríguez-Suárez J, Santos F. Effects of growth hormone treatment on growth plate, bone,and mineral metabolism of young rats with uremia induced by adenine. Pediatr Res. 2017;82:148-154.
• Sánchez-Illana Á, Núñez-Ramiro A, Cernada M, Parra-Llorca A, Valverde E, Blanco D, Moral-Pumarega MT, Cabañas F, Boix H, Pavon A, Chaffanel M, Benavente-Fernández I, Tofe I, Loureiro B, Fernández-Lorenzo JR, Fernández-Colomer B, García-Robles A, Kuligowski J, Vento M; HYPOTOP Study Group. Evolution of Energy Related Metabolites in Plasma from Newborns with Hypoxic-Ischemic Encephalopathy during Hypothermia Treatment. Sci Rep. 2017 Dec 6;7(1):17039.
• A. Sariego, C. Rey, A. Medina, J. Mayordomo, A. Concha, B. Prieto, A. Vivanco. C-reactive protein, procalcitonin and interleukin-6 in kinetics in pediatric postoperative patients. J Crit Care.2017 Oct; 41:119-123.
• González R, Bustiza A, Fernández SN, García M, Rodríguez S, García-Teresa MA, Gaboli M, García S, Sardón O, García D, Salcedo A, Rodríguez A, Luna MC, Hernández A, González C, Medina A, Pérez E, Callejón A, Toledo JD, Herranz M, López-Herce J. Quality of life in homeventilated children and their families. Eur J Pediatr. 2017 Oct;176(10):1307-1317.
• Gil-Peña H, Gómez J, Santos F, Coto E, Arango A, Hernandez O, Rodríguez J, Nadal I, Cantos V, Chocrón S, Vergara I, Madrid Á, Vazquez C, González LE, Blanco F. Primary distal renal tubular acidosis: novel findings in patients studied by next-generation sequencing. Pediatr Res. 2016; 7: 496-501.
• Santos F, Ordóñez FA, Claramunt-Taberner D, Gil-Peña H. Clinical and laboratory approaches in the diagnosis of renal tubular acidosis. Pediatr Nephrol. 2015; 30:2099-107.
• Ariceta G, Lara E, Camacho JA, Oppenheimer F, Vara J, Santos F, Muñoz MA, Cantarell C, Gil Calvo M, Romero R, Valenciano B, García-Nieto V, Sanahuja MJ, Crespo J, Justa ML, Urisarri A, Bedoya R, Bueno A, Daza A, Bravo J, Llamas F, Jiménez Del Cerro LA. Cysteamine (Cystagon®) adherence in patients with cystinosis in Spain: successful in children and a challenge in adolescents and adults. Nephrol Dial Transpl. 2015; 30:475-80.
• Tavira B, Gómez J, Santos F, Gil H, Alvarez V, Coto E. A labor- and cost-effective non-optical semiconductor (Ion Torrent) next-generation sequencing of the SLC12A3 and CLCNKA/B genes in Gitelman's syndrome patients. J Hum Genet. 2014; 59:376-80.
• Gil-Peña H, Mejía N, Santos F. Renal tubular acidosis. J Pediatr. 2014; 164:691-698.e1. Santos F, Fuente R, Mejia N, Mantecon L, Gil-Peña H, Ordoñez FA. Hypophosphatemia and growth. Pediatr Nephrol. 2013; 28:595-603.
• Riobello C, Gómez J, Gil-Peña H, Tranche S, Regu ero JR, de la Hera JM, Delgado E, Calvo D, Morís C, Santos F, Coto-Segura P, Iglesias S, Alonso B, Alvarez V, Coto E. KCNQ1 gene variants in the risk for type 2 diabetes and impaired renal function in the Spanish Renastur cohort. Mol Cell Endocrinol. 2016; 427:86-91.
• Claramunt D, Gil-Peña H, Fuente R, García-López E, Loredo V, Hernández-Frías O, Ordoñez FA, Rodríguez-Suárez J, Santos F. Chronic kidney disease induced by adenine: a suitable model of growth retardation in uremia. Am J Physiol Renal Physiol. 2015; 309:F57-62.
• Álvarez-García Ó, García-López E, Loredo V, Gil-Peña H, Mejía-Gaviria N, Rodríguez-Suárez J, Ordóñez FÁ, Santos F. Growth hormone improves growth retardation induced by rapamycin without blocking its antiproliferative and antiangiogenic effects on rat growth plate. PLoS One. 2012; 7:e34788.
• Ang L, Arboleda S, Licua G, Chuihui Y, Nan Q, Suarez M, Solís G, De Los Reyes-Gavilán GD, Gueimonde M. The establishment of the infant intestinal microbiome is not affected by rotavirus vaccination. Sci Rep. 2014; 4:7417.
• González-Iglesias H, de la Flor St Remy RR, López-Sastre J, Fernández-Colomer B, Ibáñez-Fernández A, Solís G, Sanz-Medel A, Fernández-Sánchez ML. Efficiency of iodine supplementation, as potassium iodide, during lactation: A study in neonates and their mother. Food Chem 2012; 133:859-865
• López-Vázquez A, Mozo L, Alonso-Arias R, Suárez-Álvarez B, Vidal-Castiñeira JR, Arranz E, Volta U, Bousoño C, López-Hoyos M, Rodrigo L, López-Larrea C. Autoantibodies against MHC class I polypeptide-related sequence A are associated with increased risk of concomitant autoimmune diseases in celiac patients. BMC Med. 2014. 25;12:34.
• López-Herce J, Del Castillo J, Cañadas S, Rodríguez-Núñez A, Rey C, Carrillo A, Spanish Study Group of Cardiopulmonary Arrest in Children. In-hospital pediatric cardiac arrest in Spain. Rev Esp Cardiol. 2014; 67: 189-195.
• Rey C, García-Hernández I, Concha A, Martínez-Camblor P, Botrán M, Medina A, Prieto B, López-Herce J. Pro-adrenomedullin, pro-endothelin-1, procalcitonin, C-reactive protein and mortality risk in critically ill children: a prospective study. Crit Care. 2013. 17;R240.
• López-Herce J, Ferrero L, Mencía S, Antón M, Rodríguez-Núñez A, Rey C, Rodríguez L.Teaching and training acute renal replacement therapy in children. Nephrol Dial Transpl. 2012; 27:1807-1811.
• Lobete C, Medina A, Rey C, Mayordomo-Colunga J, Concha A, Menéndez S. Correlation of oxygen saturation as measured by pulse oximetry/fraction of inspired oxygen ratio with PaO2/fraction of inspired oxygen ratio in a heterogeneous sample of critically ill children. J Critical Care. 2013; 28: 538.e1–538.e7.
• Mayordomo J, Pons M, López Y, Solana MJ, Rey C, Martinez P, Rodriguez A, López-Herce J, Medina A, Abadesso C, Gaboli M, García M, González M, Madurga P, González A, Oñate E. Predicting noninvasive ventilation failure in pediatric patients from the SPO2/FiO2 (SF) ratio. Intens Care Med. 2013; 39:1095-1103.
• De Luca D, Piastra M, Chidini G, Tissieres P, Calderini E. Essouri S, Medina Villanueva A, Vivanco Allende A, Pons Odena M, Perez Baena L, Hermon M, Tridente A, Conti G, Antonelli M, Kneyber M. Respiratory Section of the European Society for Pediatric Neonatal Intensive Care (ESPNIC). The use of Berlin definition for acute respiratory distress síndrome during infancy and early childhood: multicenter evaluation and expert consensus. Intens Care Med. 2013; 39:2083-91.

Principal Investigator	Title	Funding Body	Reference No	Duration	Amount
Fernando Santos Rodríguez	Longitudinal growth, morphology and dynamics of growth cartilage, bone structure and phosphorous metabolism in the Hyp mouse: the effect of a range of therapeutic strategies	Instituto Salud Carlos III	PI 12/00987	2013-2015	€152,460
Belén Fernández Colomer	Determination and speciation of zinc in human milk and milk formulas for nursing mothers: a study of the bioavailability and metabolism of dietary zinc supplements.	Instituto Salud Carlos III	PI 12/02409	2013-2015	€36,300
Juan José Díaz Martin	Plasma citrulline in the paediatric diagnosis and monitoring of coeliac disease	Instituto Salud Carlos III	PI12/02768	2013-2015	€21,600
Fernando Santos Rodríguez	The disturbed process of growth cartilage chondrocyte enlargement in an experimental model of uraemia: the effect of a growth hormone	Instituto Salud Carlos III	PI 15/00872	2016-2018	€41,745
Julián Rodríguez Suárez	Diagnostic advances in distal renal tubular acidosis	Instituto Salud Carlos III	PI 14/00702	2015-2017	€25,228.50
Fernando Santos Rodríguez	Paediatric Research Group	European Regional Development Fund	GRUPIN 14-020	2015-2017	€100,800
Belén Fernández Colomer	The effect of Holder pasteurisation on the content and speciation of trace elements in breast milk: a study of the bioavailability of Fe nanoparticle fortified milk	Instituto Salud Carlos III	PI 16/02084	2017-2019	€62,315

Supervisors	Title	PhD Student	Organisation	Date of Viva
Juan José Díaz	Utility of a rapid antigen technique in the diagnosis ofacute pharyngotonsillitis caused by Streptococcus pyogenes in the paediatric population	Alejandro Perez Guirado	Universidad de Oviedo	2017
Corsino Rey Galán	Paediatric mortality: how families and nurses cope, and analysis and quality of care	María del Rosario Riestra Rodriguez	Universidad de Oviedo	2017
Alberto Medina VillanuevaCorsino Rey Galán	Kinetics of reactive C-protein, procalcitonin and interleukin 6 after different types of surgery	Andrea Sariego Jamardo	Universidad de Oviedo	2017

Multicentre, Randomised, Blinded Clinical Study Comparing Early Use of Total Body Moderate Hypothermia plus Topiramate or Placebo in Asphyxiated Newborn Infants Evolving to Moderate-to-severe Hypoxic Ischaemic Encephalopathy

• Code: HYPOTOP Study.
• EudraCT No: 2011-00 5696-17.
• Sponsor: Instituto de Investigación La Fe (La Fe Research Institute).
• Duration: 2012-2017

A Multicentre, Randomised, Placebo-Controlled Study of SBC-102 in Patients with Lysosomal Acid Lipase Deficiency

• Code: Synageva LAL-CL02 Study
• Sponsor: SYNAGEVA

Corticosteroids for preventing post-extubation complications in the airway of critically-ill children.

• Code: FIBHGM-ECNC003-2010 (FIBHGM-10-01)
• Sponsor: Fundación Para la Investigación Biomédica del Hospital Gregorio Marañón (Hospital Gregorio Marañón Foundation for Biomedical Research)

Multicentre, Randomised, Blinded Clinical Study Comparing Early Use of Total Body Moderate Hypothermia plus Topiramate or Placebo in Asphyxiated Newborn Infants Evolving to Moderate-to-severe Hypoxic Ischaemic Encephalopathy.

• Sponsor: Instituto de Investigación La Fe
• HYPOTOP Study.
• EudraCT No:2011-00 5696-17.
• Duration: 2012-2017

Synageva LAL-CL02 Study: A Multicentre, Randomised, Placebo-Controlled Study of SBC-102 in Patients with Lysosomal Acid Lipase Deficiency

• Sponsor: SYNAGEVA.
• Completed in: 2015-2017

• National Nutrition Day Talks (28/5/2019)