Juan Pablo Rodrigo Tapia (Guadalajara,1966) gained his degree in Medicine from the Universidad de Oviedo (1989), for which he received the Outstanding Degree Award. Between 1991 and 1994, he completed the Ear, Nose and Throat specialist training at HUCA, and a three-month placement at the UCLA School of Medicine (CA, US). In 1995, he obtained a PhD in Medicine from the Universidad de Oviedo.
He has worked as an Ear, Nose and Throat Specialist at the Hospital de León (1995-1998) and HUCA (1998-2008). In 2008, he gained the post of Clinical Lecturer in Otolarynology at the Universidad de Oviedo-HUCA, and in 2016 became a University Professor.
He is Director of the Department of Surgery and Medical-Surgical Specialities, Editor-in-Chief of the Acta Otorrinolaringológica Española journal, and member of the International Head and Neck Scientific Group and the Collegium Oto-Rhino-Laryngologicum Amicitiae Sacrum.
Having authored over 250 scientific publications, he has a H-index of 33 and has been classified as one of the world’s top 10 experts in larynx cancer.
María Dolores Chiara Romero
María Dolores Chiara Romero is an I3 Senior Researcher in the Spanish National Health System (SNS). She obtained a Bachelor’s degree and PhD in Medicine and Surgery from the Universidad de Sevilla in 1986 and 1990, respectively, and was a postdoctoral fellow in the Cardiology and Cellular Biology departments of Harvard University from 1991 to 1996, before continuing her postdoctoral research in the Medical Physiology department of the Universidad de Sevilla (1996-2002). She has received grants from the Junta de Andalucía (Regional Government of Andalusia), the Real Colegio Complutense at Harvard University, the Spanish Ministry of Education and Science, NATO, Harvard University and CSIC. Between 1999 and 2002, she was a Miguel Servet Researcher (Hospital Virgen del Rocío, Seville) and an Associate Lecturer (Universidad de Sevilla). She has been a Tenured Lecturer in Physiology at the Universidad de Sevilla since 2002 (currently on voluntary sabbatical). From 2002 to 2008, she was a Miguel Servet Researcher at HUCA and she has been an I3-SNS Researcher at this hospital since 2008. Her current research focuses on investigating the pathogenic mechanisms of metastasis.
Marinus A.J.A. Hermsen
Dr Mario Hermsen studied Biochemistry at Wageningen University (the Netherlands), and obtained his PhD in Medicine from Vrije Universiteit Amsterdam in 2002. Between 1995 and 2003, he investigated the genetics of the progression from colorectal adenomas to carcinomas in the Pathology Department of Vrije Universiteit Amsterdam. He has been a member of the Head and Neck Cancer research group since 2003, during which time his work has focused on nasal and sinus cancer.
The nasal cavities and sinuses can host a wide range of tumours, which are generally poorly differentiated and do not have a good prognosis, despite advances in surgery and radiotherapy. In Dr Hermsen’s laboratory, several approaches are taken to tumour genome characterisation, in order to identify genetic variants that may assist with diagnosis and improve prognosis and treatment. Additionally, the genetic variants identified are studied and tested in preclinical situations as possible targets for personalised therapies with specific inhibitors.
Hospital Universitario Central de Asturias
Edificio FINBA. Planta 0
Avenida Hospital Universitario s/n, 33011 Oviedo, Spain.
Telephone: +34 615052748
E-mail: jprodrigo@uniovi.es
| Name | Organisation | Activity | Euraxess classification |
|---|---|---|---|
| Álvarez Fernández, Mónica | FINBA | Research | R2 |
| Álvarez González, Miguel | FINBA | Research | R1 |
| Álvarez Marcos, César Antonio | Universidad de Oviedo | Research/Clinical/Teaching | R3 |
| Álvarez Teijeiro, Saúl | FINBA | Research | R2 |
| Casanueva Muruais, Rodrigo | SESPA | Research/Clinical | R1 |
| Celada Crespo, Lucía | FINBA | Research | R1 |
| Chiara Romero, María Dolores | FINBA | Research | R3 |
| Coca Pelaz, Andrés | SESPA | Research/Clinical/Teaching | R2 |
| Cubiella Victorero, Tamara | Universidad de Oviedo | Research | R1 |
| del Río Ibisate, Nagore | Universidad de Oviedo | Research | R1 |
| Fernández García, María Soledad | SESPA | Research/Clinical/Teaching | R2 |
| Fernández Vañes, Laura | SESPA | Research/Clinical | R2 |
| Galache Osuna, Cristina | SESPA | Research/Clinical | R2 |
| Gancedo Verdejo, Pablo | Universidad de Oviedo | Research | R1 |
| García Marín, María del Rocío | FINBA | Research | R2 |
| García Pedrero, Juana María | FINBA | Research | R3 |
| García-Cabo Herrero, Patricia | SESPA | Research/Clinical | R2 |
| Granda Díaz, Rocío | FINBA | Research | R1 |
| Grilli , Gianluigi | Universidad de Oviedo | Research | R1 |
| Grobas Álvarez, Jaime | SESPA | Research/Clinical | R2 |
| Hermida Prado, Francisco | Universidad de Oviedo | Research | R2 |
| Hermsen , Mario | FINBA | Research | R3 |
| Llorente Pendás, José Luis | Universidad de Oviedo | Research/Clinical/Teaching | R3 |
| López Álvarez, Fernando | SESPA | Research/Clinical/Teaching | R2 |
| López Fernández, Ana María | FINBA | Research | R1 |
| Lorenzo Guerra, Sara Lucila | FINBA | Research | R1 |
| Menéndez Del Castro, Marta | SESPA | Research/Clinical | R1 |
| Montoro Jiménez, Irene | FINBA | Research | R1 |
| Núñez Batalla, Faustino | SESPA | Research/Clinical/Teaching | R2 |
| Otero Rosales, María | FINBA | Research | R1 |
| Pedregal Mallo, Daniel | SESPA | Research/Clinical | R2 |
| Prieto Fernández, Llara | Universidad de Oviedo | Research | R1 |
| Pozo Agundo, Esperanza | FINBA | Research | R1 |
| Reda del Barrio, Sara | SESPA | Research/Clinical | R2 |
| Rodrigo Tapia, Juan Pablo | Universidad de Oviedo/SESPA | Research/Clinical/Teaching | R4 |
| Sánchez Canteli, Mario | SESPA | Research/Clinical | R2 |
| Sánchez Fernández, Paula | SESPA | Research/Clinical | R2 |
| Sánchez Fernández, Rafael | SESPA | Research/Clinical | R2 |
| Santos-Juanes Jiménez, Jorge | SESPA/Universidad de Oviedo | Research/Clinical/Teaching | R3 |
| Suárez Fente, Vanessa | SESPA | Research/Clinical | R2 |
| Suárez Gordillo, Andrea | FINBA | Research | R1 |
| Tirados Menéndez, Sofía | Universidad de Oviedo | Research | R2 |
| Villanueva Fernández, Eva | SESPA | Research | R1 |
| Vivanco Allende, Blanca | SESPA | Research/Clinical/Teaching | R2 |
| Bestilleiro Márquez, Judit | Universidad de Oviedo | Research | No classification |
| Codina Martínez, Helena | CIBER | Research | No classification |
| Naves Cabal, Virginia | FINBA | Research | No classification |
| Suárez Fernández, Laura | FINBA | Research | No classification |
The research group is made up of a multidisciplinary team, including clinical researchers who perform their clinical practice in the Ear, Nose and Throat, Pathological Anatomy and Dermatology Services of the Hospital Universitario Central de Asturias (HUCA), and basic researchers from the Head and Neck Cancer Research Unit of the Instituto Universitario de Oncología del Principado de Asturias (IUOPA). These researchers have extensive knowledge and research experience in tumour biology of the head and neck area, as well as solid training in using the necessary methodology and technology for conducting research projects.
Our group has carried out a significant amount of multidisciplinary research over the last 15 years. The success of this cooperative work is demonstrated by the group’s scientific output, details of which are contained in the IUOPA annual report, https://www.unioviedo.es/IUOPA/?page_id=138&lang=es/, and our research group’s page on the Universidad de Oviedo website, http://iocc.grupos.uniovi.es/investigacion/produccion. In summary, over the last five years, 24 PhD theses have been completed within our group, 150 articles have been published in JCR-ranked journals (70 of them within the top decile, including publications in journals such as Nature Communications, Lancet Oncology, Nature Reviews Clinical Oncology, Stem Cells and Journal of Pathology), and over 200 presentations have been delivered at national and international conferences.
Our group has received continuous funding since 2007 as a member of the RTICC (Thematic Network for Cooperative Cancer Research; RD06/0020/0034 and RD12/0036/0015), and part of CIBER (Network Centre for Biomedical Research: Cancer thematic area; CB16/12/00390) since 2017. It has also been recognised as a Consolidated Research Group by the Principado de Asturias (GRUPIN14-003).
Current and Future Priorities
Our research efforts are currently focused on identifying the molecular and physiopathological basis of head and neck malignancies and the consequences of tumour initiation, invasion and cancer metastasis, relapse and therapeutic efficacy. This research should provide detailed information on any signalling molecules/biochemical pathways identified as relevant and clinically useful characteristics for diagnosis/prognosis, as well as new treatment objectives for head and neck cancer, using the following strategies:
- Identification and validation of cancer risk markers in premalignant lesions, for application in clinical practice.
- The use of biofluids (especially saliva) as an easier way of detecting the pre-identified biomarkers, or as a source of a wide range of new biomarkers, based on the analysis of nucleic acids, proteins, metabolites and microbiota.
- Identification and molecular characterisation of the pathways involved in tumour progression, by studying cellular motility, individual and collective cell invasion and cell-cell interactions through various mechanisms (adhesion molecules, secreted factors and long-distance interactions).
- The role of the tumour microenvironment, and particularly of cancer-associated fibroblasts, as a possible driver of the cancer’s progression and therefore a potential source of new diagnostic or therapeutic targets.
- Generation of relevant cell and animal models for the disease, in order to perform functional in vivo analysis.
- Identification and molecular characterisation of cancer stem cells, as part of the search for new treatments targeting these subpopulations.
- Development of new strategies for delivering drugs, based on nanotechnology.
Our research group aims to advance knowledge of the processes of initiation, relapse and metastasis in four types of tumours: epidermoid carcinomas of the head and neck; nasal and sinus carcinomas; paragangliomas, and sarcomas. We hope that the advances achieved contribute to the discovery of new biomarkers and treatments.
- AUTHORS: Llorente JL, López F, Suárez C, Hermsen MA.
TITLE: Sinonasal carcinoma: clinical, pathological, genetic and therapeutic advances.
Nat Rev Clin Oncol. 2014;11:460-72. PMID:24935016. Review. IF:14.18 (Q1). - AUTHORS: Llanos S, García-Pedrero JM, Morgado-Palacin L, Rodrigo JP, Serrano M.
TITLE: Stabilization of p21 by mTORC1/4E-BP1 predicts clinical outcome of head and neck cancers.
Nat Commun. 2016;7:10438. PMID: 26832959; Research paper. IF: 11.470 (Q1). - AUTHORS: Piazzolla D, Palla AR, Pantoja C, Cañamero M, de Castro IP, Ortega S, Gómez-López G, Dominguez O, Megías D, Roncador G, Luque-Garcia JL, Fernandez-Tresguerres B, Fernandez AF, Fraga MF, Rodriguez-Justo M, Manzanares M, Sánchez-Carbayo M, García-Pedrero JM, Rodrigo JP, Malumbres M, Serrano M.
TITLE: Lineage-restricted function of the pluripotency factor NANOG in stratified epithelia.
Nat Commun. 2014;5:4226. PMID: 24979572. Research paper. IF: 11.47 (Q1). - AUTHORS: García-Pedrero JM, Martínez-Camblor P, Diaz-Coto S, Munguia-Calzada P, Vallina-Alvarez A, Vazquez-Lopez F, Rodrigo JP, Santos-Juanes J.
TITLE: Tumor programmed cell death ligand 1 expression correlates with nodal metastasis in patients with cutaneous squamous cell carcinoma of the head and neck.
J Am Acad Dermatol. 2017 Sep;77(3):527-533; IF: 7.001 (Q1). - AUTHORS: Sáenz-de-Santa-María I, Bernardo-Castiñeira C, Secades P, Bernaldo-de-Quirós S, Rodrigo JP, Astudillo A, Chiara MD.
TITLE: Clinically relevant HIF-1α-dependent metabolic reprogramming in oropharyngeal squamous cell carcinomas includes coordinated activation of CAIX and the miR-210/ISCU signaling axis, but not MCT1 and MCT4 upregulation.
Oncotarget. 2017 Feb 21;8(8):13730-13746.IF:6,359 (Q1). - AUTHORS: Sáenz-de-Santa-María I, Bernardo-Castiñeira C, Enciso E, García-Moreno I, Chiara JL, Suarez C, Chiara MD.
TITLE: Control of long-distance cell-to-cell communication and autophagosome transfer in squamous cell carcinoma via tunneling nanotubes.
Oncotarget. 2017 Mar 28;8(13):20939-20960. IF: 6,359 (Q1) - AUTHORS: Merlo A, Bernardo-Castiñeira C, Sáenz-de-Santa-María I, Pitiot AS, Balbín M, Astudillo A, Valdés N, Scola B, Del Toro R, Méndez-Ferrer S, Piruat JI, Suarez C, Chiara MD.
TITLE: Role of VHL, HIF1A and SDH on the expression of miR-210: Implications for tumoral pseudo-hypoxic fate.
Oncotarget. 2017 Jan 24;8(4):6700-6717. IF: 6.359 (Q1). - AUTHORS: García-Carracedo D, Villaronga MA, Álvarez-Teijeiro S, Hermida-Prado F, Santamaría I, Allonca E, Suárez-Fernández L, Gonzalez MV, Balbín M, Astudillo A, Martínez-Camblor P, Su GH, Rodrigo JP, García-Pedrero JM.
TITLE: Impact of PI3K/AKT/mTOR pathway activation on the prognosis of patients with head and neck squamous cell carcinomas.
Oncotarget 2016 7(20):29780-93. Research Paper. IF:6,359 (Q1). - AUTHORS: Tornin J, Martinez-Cruzado L, Santos L, Rodriguez A, Núñez LE, Oro P, Hermosilla MA, Allonca E, Fernández-García MT, Astudillo A, Suarez C, Morís F, Rodriguez R.
TITLE: Inhibition of SP1 by the mithramycin analog EC-8042 efficiently targets tumor initiating cells in sarcoma.
Oncotarget. 2016 ;7(21):30935-50 Research paper. IF: 6,359 (Q1). - AUTHORS: Bernardo-Castiñeira C, Valdés N, Sierra MI, Sáenz-de-Santa-María I, Bayón GF, Perez RF et al.
TITLE: SDHC Promoter Methylation, a Novel Pathogenic Mechanism in Parasympathetic Paragangliomas.
J Clin Endocrinol Metabol. 2018;103(1):295-305. IF: 5,4 (Q1) - AUTHORS: Lopez-Hernandez A., Vivanco B., Franchi A., Bloemena E., Cabal V.N., Potes S. et al.
TITLE: Genetic profiling of poorly differentiated sinonasal tumours.
Scientific Reports. 2018;8(1). IF: 4.25 (Q1) - AUTHORS: Menéndez ST, Villaronga MÁ, Rodrigo JP, Álvarez-Teijeiro S, Urdinguio RG, Fraga MF, Suárez C, García-Pedrero JM.
TITLE: HERG1A potassium channel is the predominant isoform in head and neck squamous cell carcinomas: evidence for regulation by epigenetic mechanisms.
Sci Rep. 2016;6:19666. PMID: 26785772; Research paper. IF: 5.578 (Q1). - AUTHORS: Rodrigo JP, Menéndez ST, Hermida-Prado F, Álvarez-Teijeiro S, Villaronga MÁ, Alonso-Durán L, Vallina A, Martínez-Camblor P, Astudillo A, Suárez C, María García-Pedrero J.
TITLE: Clinical significance of Anoctamin-1 gene at 11q13 in the development and progression of head and neck squamous cell carcinomas.
Sci Rep.2015 ;5:15698. PMID: 26498851; Research paper. IF:5.578 (Q1). - AUTHORS: Álvarez-Teijeiro S, Menéndez ST, Villaronga MÁ, Pena-Alonso E, Rodrigo JP, Morgan RO, Granda-Díaz R, Salom C, Fernandez MP, García-Pedrero JM.
TITLE: Annexin A1 down-regulation in head and neck squamous cell carcinoma is mediated via transcriptional control with direct involvement of miR-196a/b.
Sci Rep. 2017 Jul 28;7(1):6790. IF: 5.078 (Q1) - AUTHORS: Rodrigo JP, Villaronga MÁ, Menéndez ST, Hermida-Prado F, Quer M, Vilaseca I, Allonca E, Pedregal Mallo D, Astudillo A, García-Pedrero JM.
TITLE: A Novel Role For Nanog As An Early Cancer Risk Marker In Patients With Laryngeal Precancerous Lesions.
Sci Rep. 2017 Sep 11;7(1):11110. IF:5.071 (Q1). - AUTHORS: Rodrigo JP, Heideman DA, García-Pedrero JM, Fresno MF, Brakenhoff RH, Díaz Molina JP, Snijders PJ, Hermsen MA.
TITLE: Time trends in the prevalence of HPV in oropharyngeal squamous cell carcinomas in northern Spain (1990-2009)
Int J Cancer. 2014 ;134:487-92. PMID: 23824638. Research paper. IF: 5.085 (Q1) - AUTHORS: Martinez-Cruzado L, Tornin J, Rodriguez A, Santos L, Allonca E, Fernandez-Garcia MT, Astudillo A, Garcia-Pedrero JM, Rodriguez R.
TITLE: Trabectedin and Campthotecin Synergistically Eliminate Cancer Stem Cells in Cell-of-Origin Sarcoma Models.
Neoplasia. 2017 Jun;19(6):460-470. IF: 5,006 (Q1) - AUTHORS: Tornin J, Hermida-Prado F, Padda RS, Gonzalez MV, Alvarez-Fernandez C, Rey V, Martinez-Cruzado L, Estupiñan O, Menendez ST, Fernandez-Nevado L, Astudillo A, Rodrigo JP, Lucien F, Kim Y, Leong HS, Garcia-Pedrero JM, Rodriguez R.
TITLE: FUS-CHOP Promotes Invasion in Myxoid Liposarcoma through a SRC/FAK/RHO/ROCK-Dependent Pathway.
Neoplasia. 2018 Jan;20(1):44-56. IF: 5,006 (Q1) - AUTHORS: Fernández-Valle Á, Rodrigo JP, García-Pedrero JM, Rodríguez-Santamarta T, Allonca E, Lequerica-Fernández P, de Vicente JC.
TITLE: Expression of the voltage-gated potassium channel Kv3.4 in oral leukoplakias and oral squamous cell carcinomas.
Histopathology. 2015. doi: 10.1111/his.12917. PMID: 26648458. Research paper. IF: 3.453 (Q1) - AUTHORS: Costales M, López F, 18 García-Inclán C, Fernández S, Alvarez Marcos C, Llorente JL, Hermsen MA.
TITLE: Establishment and characterization of an orthotopic sinonasal squamous cell carcinoma mouse model.
Head Neck 2015 Dec;37(12):1769-75. PMID:24990098 Research paper. IF: 3.006 (Q1)
| Researchers | Title | Funding Body | Duration |
|---|---|---|---|
| María D. Chiara (PI) Eva Allonca Justo Gómez Rafael Sánchez Laura Santos Aida Rodríguez |
Pre-clinical model for studying the impact of intercellular transfer of organelles upon the physiopathology of HNSCCs and its modulation through hypoxia: early clinical exploration. | PI17/01901 | 2018-2020 |
| Mario Hermsen (PI) José Luis Llorente Pendás Fernando López María Costales Marcos Cristina García Inclán Sira Potes Ares |
Analysis through massive sequencing of actionable gene mutations for the personalised treatment of nasal and sinus carcinomas. | AECC (CICPF16008HERM) | January 2018 – December 2020 |
| José Luis Llorente (PI) Vanessa Suárez Fente Blanca Vivanco Allende María Costales Marcos Verónica Blanco Lorenzo Virginia Naves Cabal Alessandro Franchi Reinhard Büttner |
Identification of genetic alterations in nasal and sinus tumours as targets for new therapeutic options: translational study. | ISCIII-AES 2017 (PI17/00763) | January 2018 – December 2020 |
| René Rodríguez (PI) Maria Victoria González Meana Sofía Tirados Menéndez Óscar Estupiñán Sánchez Verónica Rey Vázquez |
Precision medicine strategy in sarcomas, based on the use of primary patient-derived cultures. (GEIS-62) | Grupo Español de Investigación en Sarcomas (Spanish Sarcoma Research Group, GEIS) | October 2017 – October 2019 |
| René Rodríguez González (PI) María Victoria González Meana Oscar Estupiñán Sánchez Juan Tornín Cavielles Lucía Martínez Cruzado Verónica Blanco Lorenzo Carlos Álvarez Fernández María Soledad Fernández García Cesar Antonio Álvarez Marcos Alejandro Braña Vigil Faustino Núñez Batalla Maria Teresa Fernández García Aida Rodríguez Pérez María Matos González Gemma Gutierrez Cervelló |
Development of therapeutic strategies targeting the subpopulations of cancer stem cells in sarcomas. | Ministerio de Economía y Competitividad.
RDI Projects – Societal Challenges. (SAF2016-75286-R) |
October 2016 – December 2019 |
| Juan Pablo Rodrigo (PI) Juana M García Pedrero M Angeles Villaronga Juan Carlos de Vicente Lucas de Villalaín Eva Allonca Charles Lawrie Lorea, Manterola Ángel Ispizua Álex Sistiaga Ekhiñe Larruskain. |
New non-invasive markers in saliva for diagnosis and clinical follow-up of patients with head and neck cancer. Fundación MERCK SALUD (17-CC-008) | Private funding | September 2017 – December 2019 |
| J.M. García Pedrero (PI) J.P. Rodrigo Tapia (Co-PI) L. de Villalaín Álvarez A. Coca Pelaz C. Alvarez Marcos M.S. Fernández García E. Allonca Campa F.J. Hermida Prado A. Rodríguez Pérez |
Diversifying the search for novel biomarkers with potential clinical utility for diagnosis, prognosis or novel therapeutic targets in patients with head and neck cancer | Instituto de Salud Carlos III (Carlos III Health Institute) – AES2016 (PI16/00280) | January 2017 – December 2019 |
| J.P. Rodrigo Tapia (Coordinator) J.L. Llorente Pendás C. Álvarez Marcos F. López Álvarez M. Costales Marcos A. Coca Pelaz M.A. Hermsen M.D. Chiara Romero J.M. García Pedrero M.V. González Meana M.Á. Villaronga Torres S. Tirados Menéndez S. Alvarez Teijeiro F.J. Hermida Prado E. Allonca Campa |
Molecular mechanisms, models of carcinogenesis, biomarkers and pre-clinical validation of new therapeutic targets in respiratory tract tumours | Instituto de Salud Carlos III – CIBER: Cancer thematic area (CB16/12/00390) | 2017 – 2018 |
| ENTRECHEM,S.L., in collaboration with FUNDACION PARA EL FOMENTO EN ASTURIAS DE LA INVESTIGACION CIENTIFICA APLICADA Y LA TECNOLOGIA (Foundation for the Promotion of Applied Scientific Research and Technology in Asturias; René Rodríguez González, PI: Oscar Estupiñán Sánchez; Lucía Martínez Cruzado, Head and Neck Cancer Research Group), INSTITUT DE RECERCA CONTRA LA LEUCEMIA JOSEP CARRERAS (Josep Carreras Leukaemia Research Institute; Pablo Menéndez Buján) and the UNIVERSIDAD DE OVIEDO (Carmen Rodríguez Sánchez, Morphology and Cell Biology Department; Serafín Marcos Costilla García, Preclinical Imaging Laboratory; José Luis Llorente Pendás, Surgery and Medical-Surgical Specialities Department, Head and Neck Cancer Research Group) | Setting the dosage and efficacy studies of indolocarbazole EC-70124 in predictive animal models. (INDOLKIN) | MINISTERIO DE ECONOMÍA Y COMPETITIVIDAD: Challenges – Collaboration within the State Programme for Research, Development and Innovation Focusing upon Societal Challenges. (RTC-2016-4603-1) | January 2016 – December 2018 |
| M. Hermsen F. López Álvarez B. Vivanco Allende M. Costales Marcos S. Potes Ares C. García Inclán |
New options for the treatment and early diagnosis of nasal and sinus carcinomas | Instituto de Salud Carlos III – AES2015 (PI15/1629) | January 2016 – December 2018 |
| María Dolores Chiara (PI) Nuria Valdés |
Validation and functional analysis of the epigenetic changes present in metastatic neuroendocrine tumours associated with germline mutations in SDH genes: physiopathological implications | Grupo Español de Tumores Neuroendocrinos (Spanish Neuroendocrine Tumours Group) | January 2016 – December 2017 |
| María Dolores Chiara (PI) Inmaculada García-Moreno |
Photonic materials as bioimage markers (Thematic Network) | Ministerio de Economia y Competitividad | 2016 – 2017 |
| C. Suárez Nieto (PI) J.L. Llorente Pendás J.P. Rodrigo Tapia C. Álvarez Marcos F. López Álvarez M.Costales Marcos F. Núñez Batalla A. Coca Pelaz S. Fernández García B.M. Vivanco Allende M.A.Hermsen M.D. Chiara Romero J.M. García Pedrero R. Rodríguez González M.V. González Meana M.Alonso Guervós M.Á. Villaronga Torres S. Tirados Menéndez V. Suárez Fente S. Bernaldo de Quirós F.J. Hermida Prado L. Martínez Cruzado C. García Inclán I. Sáenz de Santamaría E. Allonca Campa S. Potes Ares L. Santos Duque |
Public research organisation grants for research groups | FICYT (GRUPIN14-003) | January 2015 – December 2017 |
| Carlos Suárez Nieto (PI), César Álvarez Marcos María Dolores Chiara Romero Andrés Coca Pelaz Blanca Vivanco Allende Marta Garzón Arango Jorge García Martínez Sira Potes Ares María Ángeles Villaronga Torres Mario Hermsen Maria Soledad Fernández García Eva Allonca Campa Juan Pablo Rodrigo Tapia Anna Merlo María Cristina García Inclan Fernando López Álvarez Sandra Bernaldo de Quirós Fernández Iriana Zambrano Andazol. PI11/00929 (Intrasalud) PI: Carlos Suárez Nieto |
Genetic and molecular alterations involved in the development and progression of head and neck cancers and clinical implications | FA: Instituto de Salud Carlos III, Madrid, Spain | 2012 – 2015 |
| J.M. García Pedrero J.C. de Vicente Rodríguez F. Núñez Batalla L. de Villalaín Álvarez A. Coca Pelaz S. Tirados Menéndez M.A. Villaronga Torres M.S. Fernández García S. Álvarez Teijeiro E. Allonca Campa L. Alonso Durán. PI13/00259 PI: Juana María García Pedrero |
Markers of cancer risk, progression and metastasis in head and neck cancers and their potential clinical application as therapeutic targets | FA: Instituto de Salud Carlos III, Madrid, Spain | 2014 – 2016 |
| PhD Student | Supervisors | Title | Date of Viva | University | Honours |
|---|---|---|---|---|---|
| Ruth Rubio Amador | René Rodríguez González Pablo Menéndez Buján |
Sarcomagenesis models based on mesenchymal stem cells: the influence of p53 and RB | 10-06-2013 | Universidad de Granada | |
| Gustavo Jesús Alvarez Alija | J. M. García Pedrero J. P. Rodrigo Tapia |
Cortactin and AMAP1 in epidermoid carcinomas of the head and neck: involvement in invasion and metastasis processes | 04-04-2013 | Universidad de Oviedo | |
| Patricia Martínez González | J. P. Rodrigo Tapia J. M. García Pedrero |
Molecular markers of metastasis at a distance in hypopharyngeal and laryngeal carcinomas | 28-11-2014 | Universidad de Oviedo | |
| Rocío González Márquez | J.L. Llorente Pendás M. Hermsen |
Analysis of the SOX2 gene in squamous cell carcinomas of the head and neck | 22-12-2014 | Universidad de Oviedo | |
| Carla Moreno Galindo | J. P. Rodrigo Tapia M. Hermsen |
Molecular markers of response to chemotherapy in epidermoid laryngeal and hypopharyngeal carcinomas | 13-03-2015 | Universidad de Oviedo | |
| Blanca Vivanco Allende | J. L. Llorente Pendás M. Hermsen |
The immunohistochemical profile of nasal and sinus, intestinal-type adenocarcinomas and premalignant lesions | 30-06-2014 | Universidad de Oviedo | |
| Anna Merlo | M.D. Chiara C. Suárez |
Molecular mechanisms involved in the pathogenesis of head and neck paragangliomas | 23-09-2014 | Universidad de Oviedo | |
| Maria Cristina Garcia Inclan | J. L. Llorente Pendás M. Hermsen |
The NFkB pathway as target for a new anticancer drug in head and neck squamous carcinoma | 19-06-2015 | Universidad de Oviedo (International PhD) | |
| Gonzalo Mancebo Mata | JP Rodrigo JM García Pedrero |
Molecular markers of progression in premalignant laryngeal lesions | 03-06-2016 | Universidad de Oviedo | |
| Alvaro Fernández del Valle | JC Vicente, JP Rodrigo |
Expression of the Herg1 and Kv 3. 4 potassium channels in lesions with the potential to become cancerous and in epidermoid carcinomas of the oral cavity. Usefulness as a marker of malignant transformation and progression of the disease | 04-07-2016 | Universidad de Oviedo | |
| Lucía Martínez Cruzado | René Rodríguez González | Cancer stem cells in sarcomas: the anti-tumour effect of trabectedin | 07-07-2017 | Universidad de Oviedo | |
| Saúl Álvarez Teijeiro | J.M. García Pedrero J.P. Rodrigo Tapia |
Deregulation of Annexin A1 and miR-196 in head and neck squamous cell carcinomas and the functional role of cancer-associated fibroblasts in the tumour microenvironment | 30-06-2017 | Universidad de Oviedo | International Honours |
| Juan Tornin Cavielles | René Rodríguez González | Characterisation of molecular alterations in a human myxoid liposarcoma generated from mesenchymal stem cells | 29-06-2017 | Universidad de Oviedo | |
| Inés Sáenz de Santamaria Fernández | M.D. Chiara C. Suárez |
The relevance of intercellular communication and the tumour microenvironment in the progression of epidermoid carcinomas | 23-06-2017 | Universidad de Oviedo | |
| Fabián García Velasco | J.P. Rodrigo Tapia M. Hermsen |
Human papillomavirus infection in epidermoid carcinomas in the larynx, hypopharynx and oropharynx | 14-06-2017 | Universidad de Oviedo | |
| Alejandro López Hernandez | J. L. Llorente Pendás M. Hermsen |
Nasal and sinus cancer: genetic characterisation and classification of poorly differentiated tumours | 09-06-2017 | Universidad de Oviedo | International honours |
| Esteban Reinaldo Pacheco Coronel | J.L. Llorente Pendás M. Hermsen |
Analysis of ALK, RET and ROS receptor tyrosine kinases in nasal and sinus adenocarcinomas | 28-04-2018 | Universidad de Oviedo | |
| Francisco José Hermida Prado | Juana María García Pedrero María Ángeles Villaronga Torres |
Identification of new biomarkers and therapeutic targets for the diagnosis and clinical management of patients with squamous cell carcinomas of the head and neck | 25-05-2018 | Universidad de Oviedo | International honours |
| Gabriela Muñoz Cordero | Mario Hermsen Fernando López Álvarez |
A study of the cell signalling pathway of PI3K-AKT-mTOR in nasal and sinus epidermoid carcinomas | 31-05-2018 | Universidad de Oviedo | |
| Míriam González Guerrero | Juan Pablo Rodrigo Tapia Jorge Santos-Juanes Jiménez |
A study of the clinical-pathological prognostic factors of cutaneous squamous cell carcinomas of the head and neck | 22-06-2018 | Universidad de Oviedo |
| Inventors | Title | Application No | Priority country | Registration date | Owner |
|---|---|---|---|---|---|
| Jose Luis Chiara Romero; Inmaculada García-Moreno Gonzalo; Alberto Blazquez Moraleja; María Dolores Chiara Romero; Inés Sáenz de Santa María. | First fluorescent probes for mitochondria in live cells based on BODIPY dyes functionalised by L-carnitine. | P201730885 | Spain | 04-07-2017 | CSIC |
